Rabbit CHORDC1 / CHP1 Polyclonal Antibody | anti-CHORDC1 antibody

Rabbit Polyclonal to Human CHORDC1 / CHP1

Cat. Num. AAA246870

• Gene Names: CHORDC1; CHP1
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Immunocytochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: CHORDC1 / CHP1; Polyclonal Antibody; Rabbit Polyclonal to Human CHORDC1 / CHP1; Anti-CHORDC1 / CHP1 Antibody (N-Terminus) IHC-plus; CHORDC1; CHORD-containing protein 1; CHP-1; Protein morgana; Human CHORDC1; CHP1; anti-CHORDC1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Human CHORDC1
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 332

• Applicable Applications for anti-CHORDC1 antibody: Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA, ICC, IHC-P (5 ug/ml), WB (1 - 2 ug/ml); Usage: CHORDC1 antibody can be used for detection of CHORDC1 by Western blot at 1-2 ug/ml.
• Target Species: Human
• Immunogen Description: A 21 amino acid peptide near the amino terminus of human CHORDC1.
• Immunogen Type: Synthetic peptide
• Immunogen: CHORDC1 / CHP1 antibody was raised against a 21 amino acid peptide near the amino terminus of human CHORDC1.
• Antigen Modification: N-Terminus
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-CHORDC1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunofluorescence (IF)

(Immunofluorescence of CHORDC1 in 293 cells with CHORDC1 antibody at 20 ug/ml.)

Immunocytochemistry (ICC)

(Immunocytochemistry of CHORDC1 in 293 cells with CHORDC1 antibody at 2.5 ug/ml.)

Western Blot (WB)

(Western blot of CHORDC1 in 293 cell lysate with CHORDC1 antibody at (A) 1 and (B) 2 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 221316566
• NCBI GeneID: 26973
• NCBI Accession #: NP_036256.2
• NCBI GenBank Nucleotide #: NM_012124.2
• UniProt Accession #: Q9UHD1; Q6IN49; Q8WVL9; Q9H3D6; B2R6P8
• Molecular Weight: 35,286 Da
• NCBI Official Full Name: cysteine and histidine-rich domain-containing protein 1 isoform a
• NCBI Official Synonym Full Names: cysteine and histidine-rich domain (CHORD) containing 1
• NCBI Official Symbol: CHORDC1
• NCBI Official Synonym Symbols: CHP1
• NCBI Protein Information: cysteine and histidine-rich domain-containing protein 1; CHP-1; protein morgana; CHORD-containing protein 1; chord domain-containing protein 1; cysteine and histidine-rich domain (CHORD)-containing 1; cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1
• UniProt Protein Name: Cysteine and histidine-rich domain-containing protein 1
• Protein Family: Cysteine and histidine-rich domain-containing protein
• UniProt Gene Name: CHORDC1
• UniProt Synonym Gene Names: CHP1; CHORD-containing protein 1; CHP-1
• UniProt Entry Name: CHRD1_HUMAN

Uniprot Description

CHORDC1: Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 11q14.3

Molecular Function: protein binding; zinc ion binding; Hsp90 protein binding