Rabbit CHMP4B Polyclonal Antibody | anti-CHMP4B antibody

CHMP4B

Cat. Num. AAA8563531

• Gene Names: CHMP4B; SNF7; CTPP3; Shax1; CHMP4A; SNF7-2; VPS32B; CTRCT31; Vps32-2; C20orf178; dJ553F4.4
• Reactivity: Human; Predicted: Rat, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Purified By Antigen Affinity Column
• Synonyms: CHMP4B; Polyclonal Antibody; Purified Rabbit Anti Human CHMP4B Polyclonal antibody; SNF7; CTPP3; Shax1; CHMP4A; SNF7-2; VPS32B; CTRCT31; Vps32-2; C20orf178; dJ553F4.4; anti-CHMP4B antibody

• Host: Rabbit
• Reactivity: Human; Predicted: Rat, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified By Antigen Affinity Column
• Form/Format: Already dissolved in sterile H2O with 1% BSA and 0.02% NaN3 and 50% Glycerol.
• Sequence Length: 1638

• Applicable Applications for anti-CHMP4B antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: ELISA: 1:20000-80000; WB: 1:200-1,000; IHC: 1:100-500
• Immunogen: Recombinant fragment corresponding to 47-196aa of human CHMP4B.
• Cellular Localization: Cytoplasm, Cytosol, Late Endosome Membrane, Peripheral Membrane Protein Curated Midbody, Nucleus Envelope

Related Product Information for anti-CHMP4B antibody

Homo sapiens charged multivesicular body protein 4B (CHMP4B), mRNA

References

Katoh K, Shibata H, Hatta K. et al. CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms. Arch Biochem Biophys. 421(1):159-65 (2004)

NCBI and Uniprot Product Information

• NCBI GI #: 21708119
• NCBI GeneID: 128866
• Molecular Weight: 25KD
• NCBI Official Full Name: Homo sapiens chromatin modifying protein 4B, mRNA
• NCBI Official Synonym Full Names: charged multivesicular body protein 4B
• NCBI Official Symbol: CHMP4B
• NCBI Official Synonym Symbols: SNF7; CTPP3; Shax1; CHMP4A; SNF7-2; VPS32B; CTRCT31; Vps32-2; C20orf178; dJ553F4.4
• NCBI Protein Information: charged multivesicular body protein 4b
• Protein Family: Charged multivesicular body protein

NCBI Description

This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.[provided by RefSeq, Oct 2009]