Immunohistochemistry (IHC)
(Immunochemical staining of human CFHR1 in human hepatoma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)
Rabbit anti-Human CFHR1 Polyclonal Antibody | anti-CFHR1 antibody
Anti-CFHR1 Antibody, Rabbit Polyclonal
Gene Names
CFHR1; CFHL; FHR1; HFL1; HFL2; CFHL1; H36-1; H36-2; CFHL1P; CFHR1P
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
CFHR1; Polyclonal Antibody; Anti-CFHR1 Antibody; Rabbit Polyclonal; CFHR1 Antibody; Rabbit PAb; Antigen Affinity Purified; complement factor H related 1; Anti-CFHL Antibody; Anti-CFHL1 Antibody; Anti-CFHL1P Antibody; Anti-CFHR1P Antibody; Anti-FHR1 Antibody; Anti-H36-1 Antibody; Anti-H36-2 Antibody; Anti-HFL1 Antibody; Anti-HFL2 Antibody; anti-CFHR1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human CFHR1
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-CFHR1 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:500-1:2000
Immunogen
A synthetic peptide corresponding to the N-terminus of the Human CFHR1
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human CFHR1, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human CFHR1 in human hepatoma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)
Immunohistochemistry (IHC)
(Immunochemical staining of human CFHR1 in human hepatoma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)
Related Product Information for anti-CFHR1 antibody
CFHR1 is a secreted protein belonging to the complement factor H protein family.The human complement factor H protein family consists of the complement and immune regulators factor H, the factor H-like protein 1(FHL-1) and five factor H-related proteins (CFHR-1 to -5). Members of the H-related protein family are exclusively composed of individually folded protein domains, termed short consensus repeats (SCRs) or complement control modules. CFHR1 binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. CFHR1 might be involved in complement regulation. It can associate with lipoproteins and may play a role in lipid metabolism.
Product Categories/Family for anti-CFHR1 antibody
References
Martnez-Barrica, et al. (2012) Relevance of complement factor H-related 1 (CFHR1) genotypes in age-related macular degeneration. Invest Ophthalmol Vis Sci. 53(3):1087-94.Leban N, et al. (2012) Factor H and CFHR1 polymorphisms associated with atypical Haemolytic Uraemic Syndrome (aHUS) are differently expressed in Tunisian and in Caucasian populations. Int J Immunogenet. 39(2):110-3.Kubista KE, et al. (2011) Copy number variation in the complement factor H-related genes and age-related macular degeneration. Int J Immunogenet. Mol Vis. 17:2080-92.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
330
NCBI Official Full Name
Complement factor H-related protein 1
NCBI Official Synonym Full Names
complement factor H-related 1
NCBI Official Symbol
CFHR1
NCBI Official Synonym Symbols
CFHL; FHR1; HFL1; HFL2; CFHL1; H36-1; H36-2; CFHL1P; CFHR1P
NCBI Protein Information
complement factor H-related protein 1; H36; FHR-1; H-factor-like 1; h factor-like protein 1; H factor (complement)-like 1; H factor (complement)-like 2; complement factor H-related 1 pseudogene
UniProt Protein Name
Complement factor H-related protein 1
Protein Family
UniProt Gene Name
CFHR1
UniProt Synonym Gene Names
CFHL; CFHL1; CFHL1P; CFHR1P; FHR1; HFL1; HFL2; FHR-1; H-factor-like 1
UniProt Entry Name
FHR1_HUMAN
NCBI Description
This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009]
Uniprot Description
CFHR1: Might be involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 1q32
Cellular Component: extracellular space
Biological Process: complement activation
Disease: Macular Degeneration, Age-related, 1; Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Research Articles on CFHR1
Similar Products
Product Notes
The CFHR1 cfhr1 (Catalog #AAA8101951) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CFHR1 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CFHR1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:500-1:2000. Researchers should empirically determine the suitability of the CFHR1 cfhr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CFHR1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
