Western Blot (WB)
(Western blot analysis of extract of various cells, using CFD antibody.)
Rabbit anti-Human CFD Polyclonal Antibody | anti-CFD antibody
CFD Polyclonal Antibody
IHC: 1:50 - 1:100
Western Blot (WB)
(Western blot analysis of extract of various cells, using CFD antibody.)
Western Blot (WB)
(Western blot analysis of extract of various cells, using CFD antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human stomach using CFD antibody at dilution of1:100 (40x lens).)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human stomach using CFD antibody at dilution of1:100 (40x lens).)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015]
Uniprot Description
CFD: Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Defects in CFD are the cause of complement factor D deficiency (CFDD). CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway. Belongs to the peptidase S1 family.
Protein type: EC 3.4.21.46; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: extracellular region
Molecular Function: serine-type endopeptidase activity; serine-type peptidase activity
Biological Process: complement activation; complement activation, alternative pathway; platelet degranulation
Disease: Complement Factor D Deficiency
Research Articles on CFD
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Product Notes
The CFD cfd (Catalog #AAA2541222) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CFD Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CFD can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500 - 1:2000 IHC: 1:50 - 1:100. Researchers should empirically determine the suitability of the CFD cfd for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CFD, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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