Rabbit anti-Human CES8 Polyclonal Antibody | anti-CES8 antibody

CES8, CT (CES4A, CES8, Carboxylesterase 4A) (FITC)

Cat. Num. AAA6285285

• Gene Names: CES4A; CES6; CES8
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CES8; Polyclonal Antibody; CT (CES4A; Carboxylesterase 4A) (FITC); CES4A; Carboxylesterase 4A; anti-CES8 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-CES8 antibody: Immunohistochemistry (IHC), FLISA, Western Blot (WB)
• Application Notes: IHC: 1:10-50; FLISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: CES8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 532-561 amino acids from the C-terminal region of human CES8.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(CES8 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CES8 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Western Blot (WB)

(CES8 Antibody (C-term) western blot analysis in Sk-Br-3,T47D cell line lysates (35ug/lane).This demonstrates the CES8 antibody detected the CES8 protein (arrow).)

Product Categories/Family for anti-CES8 antibody

Antibodies; Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 298231184
• NCBI GeneID: 283848
• NCBI Accession #: NP_776176.4
• NCBI GenBank Nucleotide #: NM_173815.5
• UniProt Accession #: Q5XG92; Q6UX55; Q8N9F4; A8KAJ6; B7Z349; B7Z3L2; B7Z6R3
• Molecular Weight: 53,504 Da
• NCBI Official Full Name: carboxylesterase 8 isoform 1
• NCBI Official Synonym Full Names: carboxylesterase 4A
• NCBI Official Symbol: CES4A
• NCBI Official Synonym Symbols: CES6; CES8
• NCBI Protein Information: carboxylesterase 4A
• UniProt Protein Name: Pyrethroid hydrolase Ces2a
• UniProt Gene Name: Ces2a
• UniProt Synonym Gene Names: Ces6
• UniProt Entry Name: EST2A_MOUSE

NCBI Description

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES6, encodes a secreted enzyme, and may play a role in the detoxification of drugs and xenobiotics in neural and other tissues of the body and in the cerebrospinal fluid. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2010]

Uniprot Description

CES8: Probable carboxylesterase. Belongs to the type-B carboxylesterase/lipase family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; EC 3.1.1.-

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: extracellular space

Biological Process: metabolic process