Rabbit anti-Rat Ceruloplasmin (CP) Polyclonal Antibody | anti-CP antibody

Biotin-Linked Polyclonal Antibody to Ceruloplasmin (CP)

Cat. Num. AAA2092663

• Gene Names: CP; CP-2
• Reactivity: Rat
• Applications: Western Blot, Immunohistochemistry
• Synonyms: Ceruloplasmin (CP); Polyclonal Antibody; Biotin-Linked Polyclonal Antibody to Ceruloplasmin (CP); CP2; CER; Caeruloplasmin; Ferroxidase; Oxygen Oxidoreductase; anti-CP antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Concentration: 500ug/ml (varies by lot)
• Sequence Length: 1065

• Applicable Applications for anti-CP antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Conjugation: Biotin
• Cross Reactivity: Rat
• Immunogen: ceruloplasmin (Ala872~Gly1059)

NCBI and Uniprot Product Information

• NCBI GI #: 4557485
• NCBI GeneID: 1356
• NCBI Accession #: NP_000087.1
• NCBI GenBank Nucleotide #: NM_000096.3
• UniProt Accession #: P00450; Q14063; Q2PP18; Q9UKS4
• Molecular Weight: 122,205 Da
• NCBI Official Full Name: ceruloplasmin
• NCBI Official Synonym Full Names: ceruloplasmin
• NCBI Official Symbol: CP
• NCBI Official Synonym Symbols: CP-2
• NCBI Protein Information: ceruloplasmin
• UniProt Protein Name: Ceruloplasmin
• Protein Family: Ceruloplasmin
• UniProt Gene Name: CP

NCBI Description

The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]

Uniprot Description

CP: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense. Defects in CP are the cause of aceruloplasminemia (ACERULOP). It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances. Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2. Belongs to the multicopper oxidase family.

Protein type: Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.16.3.1; Oxidoreductase; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q24-q25.1

Cellular Component: blood microparticle; endoplasmic reticulum lumen; extracellular exosome; extracellular region; extracellular space; lysosomal membrane

Molecular Function: chaperone binding; copper ion binding; ferroxidase activity

Biological Process: cellular iron ion homeostasis; cellular protein metabolic process; copper ion transport; post-translational protein modification

Disease: Aceruloplasminemia