Rabbit anti-Human, Mouse CEP152 Polyclonal Antibody | anti-CEP152 antibody

CEP152 Rabbit Polyclonal

Cat. Num. AAA767829

• Gene Names: CEP152; MCPH4; MCPH9; SCKL5
• Reactivity: Human, Mouse
• Applications: ELISA, Immunoprecipitation, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: CEP152; Polyclonal Antibody; CEP152 Rabbit Polyclonal; anti-CEP152 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 1710

• Applicable Applications for anti-CEP152 antibody: ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
• Immunogen: Centrosomal protein 152kDa
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Testing Data

()

Western Blot (WB)

(mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS767829 (CEP152 Antibody) at dilution of 1:300)

NCBI and Uniprot Product Information

• NCBI GI #: 303304991
• NCBI GeneID: 22995
• NCBI Accession #: NP_001181927.1
• NCBI GenBank Nucleotide #: NM_001194998.1
• Molecular Weight: 189,071 Da
• NCBI Official Full Name: centrosomal protein of 152 kDa isoform 1
• NCBI Official Synonym Full Names: centrosomal protein 152
• NCBI Official Symbol: CEP152
• NCBI Official Synonym Symbols: MCPH4; MCPH9; SCKL5
• NCBI Protein Information: centrosomal protein of 152 kDa
• UniProt Protein Name: Centrosomal protein of 152 kDa
• Protein Family: Centrosomal protein
• UniProt Gene Name: CEP152
• UniProt Synonym Gene Names: KIAA0912; Cep152
• UniProt Entry Name: CE152_HUMAN

NCBI Description

This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

Uniprot Description

Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615).