Rabbit anti-Human, Mouse CEP152 Polyclonal Antibody | anti-CEP152 antibody

CEP152 Antibody

Cat. Num. AAA7131267

• Gene Names: CEP152; MCPH4; MCPH9; SCKL5
• Reactivity: Human, Mouse
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: CEP152; Polyclonal Antibody; CEP152 Antibody; centrosomal protein 152 kDa; centrosomal protein 152kDa; centrosomal protein of 152 kDa; anti-CEP152 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Liquid; Rabbit IgG In Phosphate Buffered Saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% Sodium Azide and 50% Glycerol.

• Applicable Applications for anti-CEP152 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:100
• Immunogen: Synthesized peptide derived from internal of human CEP152.
• Immunogen Species: Human
• Conjugate: Non-conjugated
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human lymph node tissue using CEP152 antibody. )

Product Categories/Family for anti-CEP152 antibody

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 110347568
• NCBI GeneID: 22995
• NCBI Accession #: NP_055800.2
• NCBI GenBank Nucleotide #: NM_014985.3
• UniProt Accession #: O94986; Q17RV1; Q6NTA0
• Molecular Weight: 189,071 Da
• NCBI Official Full Name: centrosomal protein of 152 kDa isoform 2
• NCBI Official Synonym Full Names: centrosomal protein 152kDa
• NCBI Official Symbol: CEP152
• NCBI Official Synonym Symbols: MCPH4; MCPH9; SCKL5
• NCBI Protein Information: centrosomal protein of 152 kDa; asterless; microcephaly, primary autosomal recessive 4
• UniProt Protein Name: Centrosomal protein of 152 kDa
• Protein Family: Centrosomal protein
• UniProt Gene Name: CEP152
• UniProt Synonym Gene Names: KIAA0912; Cep152
• UniProt Entry Name: CE152_HUMAN

NCBI Description

This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

Uniprot Description

Function: Regulator of genomic integrity and cellular response to DNA damage acting through ATR-mediated checkpoint signaling. Necessary for centrosome duplication. It functions as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, two molecules involved in centriole formation. Ref.5 Ref.6 Ref.7

Subunit structure: Interacts (via N-terminus) with PLK4. Interacts (via C-terminus) with CENPJ (via-N-terminus). Interacts with CINP. Interacts with CEP63; this interaction recruits CEP152 to centrosomes. Ref.5 Ref.6 Ref.7 Ref.8

Subcellular location: Cytoplasm › cytoskeleton › centrosome. Note: Colocalizes with CEP63 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles. Ref.5 Ref.7 Ref.8 Ref.9

Involvement in disease: Microcephaly, primary, 9 (MCPH9) [MIM:614852]: A disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9Seckel syndrome 5 (SCKL5) [MIM:613823]: A rare autosomal recessive disorder characterized by proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe microcephaly with a bird-headed like appearance, and mental retardation.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7

Sequence caution: The sequence AAH69186.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.The sequence BAA74935.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.