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Rabbit anti-Human, Mouse CENTG1 Polyclonal Antibody | anti-CENTG1 antibody

CENTG1 (C-Term) Rabbit pAb

Gene Names
AGAP2; PIKE; GGAP2; CENTG1
Reactivity
Human, Mouse
Applications
Western Blot
Purity
Affinity Purified
Synonyms
CENTG1; Polyclonal Antibody; CENTG1 (C-Term) Rabbit pAb; Arf-GAP with GTPase; ANK repeat and PH domain-containing protein 2; AGAP-2; Centaurin-gamma-1; Cnt-g1; GTP-binding and GTPase-activating protein 2; GGAP2; Phosphatidylinositol 3-kinase enhancer; PIKE; AGAP2; KIAA0167; anti-CENTG1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Ig
Clone Number
RB19565
Purity/Purification
Affinity Purified
Form/Format
Supplied in PBS with 0.09% (W/V) Sodium Azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Sequence Length
1192
Applicable Applications for anti-CENTG1 antibody
Western Blot (WB)
Application Notes
WB: 1:2000
Immunogen
This CENTG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 850-877 amino acids from the C-terminal region of human CENTG1.
Cellular Localization
Cytoplasm, Nucleus

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
NCBI Official Full Name
PI 3-kinase enhancer long isoform
NCBI Official Synonym Full Names
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
NCBI Official Symbol
AGAP2
NCBI Official Synonym Symbols
PIKE; GGAP2; CENTG1
NCBI Protein Information
arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
UniProt Protein Name
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
UniProt Gene Name
AGAP2
UniProt Synonym Gene Names
CENTG1; KIAA0167; AGAP-2; Cnt-g1; GGAP2; PIKE
UniProt Entry Name
AGAP2_HUMAN

NCBI Description

The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Uniprot Description

CENTG1: a member of the centaurin family of ADP-ribosylation factor directed GTPase-activating proteins (GAPs). A GAP for ARF1 and ARF5. Two alternatively-spliced isoforms have been described. Isoform 1 is brain-specific, and isoform 2 is ubiquitously expressed, with highest levels in brain and heart. Isoform 1 participates to the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. Regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. The PH domains of isoforms 1 and 2 bind phospholipids, but they differentially regulate subcellular location. The PH domain of isoform 1 directs the protein to the nucleus, but the PH domain of isoform 2 directs it to the cytosol.

Protein type: Motility/polarity/chemotaxis; GAPs; GAPs, ARF; Tumor suppressor

Chromosomal Location of Human Ortholog: 12q14.1

Cellular Component: membrane; mitochondrion; nucleolus; nucleus

Molecular Function: protein binding; GTP binding; zinc ion binding

Biological Process: axon guidance; protein transport; small GTPase mediated signal transduction; negative regulation of neuron apoptosis; negative regulation of protein catabolic process; positive regulation of GTPase activity

Research Articles on CENTG1

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Product Notes

The CENTG1 agap2 (Catalog #AAA8551379) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CENTG1 (C-Term) Rabbit pAb reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CENTG1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:2000. Researchers should empirically determine the suitability of the CENTG1 agap2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CENTG1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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