Western Blot (WB)
(CENPC1 Antibody (Center) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CENPC1 antibody detected the CENPC1 protein (arrow).)
Rabbit anti-Human CENPC1 Polyclonal Antibody | anti-CENPC antibody
CENPC1, ID (CENPC1, CENPC, ICEN7, Centromere protein C 1, Centromere autoantigen C, Interphase centromere complex protein 7)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Western Blot (WB)
(CENPC1 Antibody (Center) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CENPC1 antibody detected the CENPC1 protein (arrow).)
Western Blot (WB)
(CENPC1 Antibody (Center) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CENPC1 antibody detected the CENPC1 protein (arrow).)
NCBI and Uniprot Product Information
NCBI Description
Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. Ref.10 Ref.13
Subunit structure: Oligomer. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Binds to DAXX. Interacts directly with CENPA. Ref.6 Ref.9 Ref.10
Subcellular location: Nucleus. Chromosome › centromere › kinetochore. Note: Localizes exclusively in the kinetochore domain of centromeres. Ref.7 Ref.10 Ref.13
Domain: The MIF2 homology domain II targets centromeres and binds the alpha satellite DNA in vivo. The MIF2 homology domain III can induce CENPC dimerization/oligomerization. Ref.9
Sequence similarities: Belongs to the CENPC family.
Research Articles on CENPC
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Product Notes
The CENPC cenpc (Catalog #AAA647485) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CENPC1, ID (CENPC1, CENPC, ICEN7, Centromere protein C 1, Centromere autoantigen C, Interphase centromere complex protein 7) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CENPC1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the CENPC cenpc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CENPC1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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