Rabbit anti-Rat Cell Surface Glycoprotein MUC18 Polyclonal Antibody | anti-MUC18 antibody
Cell Surface Glycoprotein MUC18 Antibody FITC
Gene Names
Mcam; CD146; Muc18
Reactivity
Rat
Applications
ELISA, Immunoprecipitation, Western Blot
Purity
Immobilized antigen affinity chromatography
Synonyms
Cell Surface Glycoprotein MUC18; Polyclonal Antibody; Cell Surface Glycoprotein MUC18 Antibody FITC; FITC-Conjugated Cell Surface Glycoprotein MUC18 Antibody; A32 antigen antibody; CD 146 antibody; Cell surface glycoprotein MUC18 antibody; Cell surface glycoprotein P1H12 antibody; Gicerin antibody; Mcam antibody; Melanoma adhesion molecule antibody; Melanoma associated antigen A32 antibody; Melanoma associated antigen MUC18 antibody; Melanoma associated glycoprotein MUC18 antibody; MelCAM antibody; MUC 18 antibody; S endo 1 antibody; S endo 1 endothelial associated antigen antibody; anti-MUC18 antibody
Host
Rabbit
Reactivity
Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Immobilized antigen affinity chromatography
Concentration
0.5-1.5 ug/ul in antibody stabilization buffer (varies by lot)
Sequence Length
606
Applicable Applications for anti-MUC18 antibody
ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
Application Notes
ELISA: 1:10,000
IP: 1:150
WB: 1:500
IP: 1:150
WB: 1:500
Immunogen
Synthetic peptide taken within amino acid region 330-353 on rat Cell Surface Glycoprotein MUC18 protein.Synthetic peptide taken within amino acid region 250-300 on rat Myeloid-associated differentiation marker.
Conjugation
FITC
Molecular Function
establishment of endothelial barrier; membrane raft organization; negative regulation of actin filament polymerization; negative regulation of gene expression; negative regulation of heterotypic cell-cell adhesion; negative regulation of protein kinase C
Subcellular Location
Cell Membrane; Single-pass type I membrane protein; Membrane Curated; Multi-pass Membrane Protein
Preparation and Storage
Store at -20 degree C for long term storage.
Related Product Information for anti-MUC18 antibody
Overview: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
Structure: Belongs to the MAL family. Contains 2 MARVEL domains.
Expression: Widely expressed. Not detected in thymus.
Structure: Belongs to the MAL family. Contains 2 MARVEL domains.
Expression: Widely expressed. Not detected in thymus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
66,683 Da
NCBI Official Full Name
cell surface glycoprotein MUC18 isoform 2
NCBI Official Synonym Full Names
melanoma cell adhesion molecule
NCBI Official Symbol
Mcam
NCBI Official Synonym Symbols
CD146; Muc18
NCBI Protein Information
cell surface glycoprotein MUC18
UniProt Protein Name
Cell surface glycoprotein MUC18
Protein Family
UniProt Gene Name
Mcam
UniProt Synonym Gene Names
Muc18
NCBI Description
may act as a cell adhesion molecule; may play a role in tumor growth and invasion [RGD, Feb 2006]
Uniprot Description
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration ().
Research Articles on MUC18
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Product Notes
The MUC18 mcam (Catalog #AAA5400536) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cell Surface Glycoprotein MUC18 Antibody FITC reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Cell Surface Glycoprotein MUC18 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB). ELISA: 1:10,000 IP: 1:150 WB: 1:500. Researchers should empirically determine the suitability of the MUC18 mcam for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cell Surface Glycoprotein MUC18, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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