Cell surface glycoprotein MUC18 Recombinant Protein | MCAM recombinant protein

Recombinant Human Cell surface glycoprotein MUC18

Cat. Num. AAA1265398

• Gene Names: MCAM; CD146; MUC18
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Cell surface glycoprotein MUC18; Recombinant Human Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; CD146; MCAM recombinant protein

• Host: E Coli
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Liquid containing glycerol
• Sequence Positions: 50-646
• Sequence: LSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGV
• Sequence Length: 646

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-Page

Related Product Information for MCAM recombinant protein

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hatogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Product Categories/Family for MCAM recombinant protein

Cell adhesion

References

MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily.Lehmann J.M., Riethmueller G., Johnson J.P.Proc. Natl. Acad. Sci. U.S.A. 86:9891-9895(1989) Genomic organization of the melanoma-associated glycoprotein MUC18 implications for the evolution of the immunoglobulin domains.Sers C., Kirsch K., Rothbaecher U., Riethmueller G., Johnson J.P.Proc. Natl. Acad. Sci. U.S.A. 90:8514-8518(1993) Identification and functional assessment of endothelial P1H12.Solovey A.N., Gui L., Chang L., Enenstein J., Browne P.V., Hebbel R.P.J. Lab. Clin. Med. 138:322-331(2001) Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004) Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Isolation and functional characterization of the A32 melanoma-associated antigen.Shih I.-M., Eleder D.E., Speicher D., Johnson J.P., Herlyn M.Cancer Res. 54:2514-2520(1994) Identification of the S-endo 1 endothelial-associated antigen.Bardin N., Frances V., Lesaule G., Horschowski N., George F., Sampol J.Biochem. Biophys. Res. Commun. 218:210-216(1996) The progression associated antigen MUC18 a unique member of the immunoglobulin supergene family.Johnson J.P., Rothbacher U., Sers C.Melanoma Res. 3:337-340(1993) Outside-in signaling pathway linked to CD146 engagement in human endothelial cells.Anfosso F., Bardin N., Vivier E., Sabatier F., Sampol J., Dignat-George F.J. Biol. Chem. 276:1564-1569(2001) A quantitative atlas of mitotic phosphorylation.Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.J. Proteome Res. 8:651-661(2009) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.Sci. Signal. 3:RA3-RA3(2010) Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011)

NCBI and Uniprot Product Information

• NCBI GI #: 71274107
• NCBI GeneID: 4162
• NCBI Accession #: NP_006491.2
• NCBI GenBank Nucleotide #: NM_006500.2
• UniProt Accession #: P43121; O95812; Q59E86; Q6PHR3; Q6ZTR2
• Molecular Weight: 70.7 kDa
• NCBI Official Full Name: cell surface glycoprotein MUC18
• NCBI Official Synonym Full Names: melanoma cell adhesion molecule
• NCBI Official Symbol: MCAM
• NCBI Official Synonym Symbols: CD146; MUC18
• NCBI Protein Information: cell surface glycoprotein MUC18
• UniProt Protein Name: Cell surface glycoprotein MUC18
• Protein Family: Cell surface glycoprotein
• UniProt Gene Name: MCAM
• UniProt Synonym Gene Names: MUC18
• UniProt Entry Name: MUC18_HUMAN