Western Blot (WB)
(CEACAM7 Antibody (Center) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the CEACAM7 antibody detected the CEACAM7 protein (arrow).)
Rabbit anti-Human CEACAM7 Polyclonal Antibody | anti-CEACAM7 antibody
CEACAM7 Antibody (Center)
Gene Names
CEACAM7; CGM2
Reactivity
Human
Applications
Western Blot, ELISA, Immunohistochemistry
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
CEACAM7; Polyclonal Antibody; CEACAM7 Antibody (Center); Carcinoembryonic antigen-related cell adhesion molecule 7; Carcinoembryonic antigen CGM2; CGM2; anti-CEACAM7 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This CEACAM7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 112-140 amino acids from the Central region of human CEACAM7.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
112-140
Sequence Length
172
Applicable Applications for anti-CEACAM7 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
Application Notes
WB~~1:1000
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Western Blot (WB)
(CEACAM7 Antibody (Center) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the CEACAM7 antibody detected the CEACAM7 protein (arrow).)
Western Blot (WB)
(CEACAM7 Antibody (Center) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the CEACAM7 antibody detected the CEACAM7 protein (arrow).)
Immunohistochemistry (IHC)
(CEACAM7 Antibody (Center) (MBS9207246)immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CEACAM7 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(CEACAM7 Antibody (Center) (MBS9207246)immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CEACAM7 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Related Product Information for anti-CEACAM7 antibody
CEA-related cell adhesion molecule 7 (CEACAM7,CGM2) belongs to the carcinoembryonic antigen (CEA) family. It encodes a glycosyl phosphatidyl inositol (GPI)-linked glycoprotein which is only found on the apical surface of highly differentiated epithelial cells adult colon and on a small epithelial cell population in pancreatic ducts. CEACAM7 expression is completely lost upon malignant transformation already in hyperplastic polyps and early adenomas as well as in adenocarcinomas of the colon. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by one immunoglobulin constantlike A domain.
References
Messick, C.A., et al. Surgery 147(5):713-719(2010)
Douard, R., et al. Surgery 139(4):556-562(2006)
Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)
Grimwood, J., et al. Nature 428(6982):529-535(2004)
Scholzel, S., et al. Am. J. Pathol. 156(2):595-605(2000)
Douard, R., et al. Surgery 139(4):556-562(2006)
Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)
Grimwood, J., et al. Nature 428(6982):529-535(2004)
Scholzel, S., et al. Am. J. Pathol. 156(2):595-605(2000)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
29379
NCBI Official Full Name
carcinoembryonic antigen-related cell adhesion molecule 7
NCBI Official Synonym Full Names
carcinoembryonic antigen-related cell adhesion molecule 7
NCBI Official Symbol
CEACAM7
NCBI Official Synonym Symbols
CGM2
NCBI Protein Information
carcinoembryonic antigen-related cell adhesion molecule 7
UniProt Protein Name
Carcinoembryonic antigen-related cell adhesion molecule 7
Protein Family
UniProt Gene Name
CEACAM7
UniProt Synonym Gene Names
CGM2
UniProt Entry Name
CEAM7_HUMAN
NCBI Description
This gene encodes a cell surface glycoprotein and member of the carcinoembryonic antigen (CEA) family of proteins. Expression of this gene may be downregulated in colon and rectal cancer. Additionally, lower expression levels of this gene may be predictive of rectal cancer recurrence. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Uniprot Description
CEACAM7: Belongs to the immunoglobulin superfamily. CEA family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Immunoglobulin superfamily; Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: integral to membrane; plasma membrane
Research Articles on CEACAM7
Similar Products
Product Notes
The CEACAM7 ceacam7 (Catalog #AAA9207246) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 112-140. The CEACAM7 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CEACAM7 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the CEACAM7 ceacam7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CEACAM7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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