Rabbit anti-Human CEACAM6 Polyclonal Antibody | anti-CEACAM6 antibody

CEACAM6, ID (CEACAM6, NCA, Carcinoembryonic antigen-related cell adhesion molecule 6, Non-specific crossreacting antigen, Normal cross-reacting antigen, CD66c) (MaxLight 550)

Cat. Num. AAA6284937

• Gene Names: CEACAM6; NCA; CEAL; CD66c
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: CEACAM6; Polyclonal Antibody; ID (CEACAM6; NCA; Carcinoembryonic antigen-related cell adhesion molecule 6; Non-specific crossreacting antigen; Normal cross-reacting antigen; CD66c) (MaxLight 550); CD66c; anti-CEACAM6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CEACAM6.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.

• Applicable Applications for anti-CEACAM6 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 188-214 in the cental region of human CEACAM6, UniProt Accession #P40199; NP_002474.3.
• Conjugate: MaxLight550
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western blot analysis in CEM cell line lysates (35ug/lane) usingMBS6003599. This demonstrates the CEACAM6 antibody detected the CEACAM6 protein (arrow).)

Related Product Information for anti-CEACAM6 antibody

Carcinoembryonic antigen (CEA; MIM 114890) is one of the most widely used tumor markers in serum immunoassay determinations of carcinoma. An apparent lack of absolute cancer specificity for CEA probably results in part from the presence in normal and neoplastic tissues of antigens that share antigenic determinants with the 180-kD form of CEA (Barnett et al., 1988 [PubMed 3220478]). For background information on the CEA family of genes, see CEACAM1 (MIM 109770).

Product Categories/Family for anti-CEACAM6 antibody

Antibodies; CD Markers

References

Wang, Y., et al. J. Clin. Invest. 119(6):1604-1615(2009). Kolla, V., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 296 (6), L1019-L1030 (2009): Litkouhi, B., et al. Gynecol. Oncol. 109(2):234-239(2008). Owaidah, T.M., et al. Hematol Oncol Stem Cell Ther 1(1):34-37(2008). Skubitz, K.M., et al. J Transl Med 6, 78 (2008).

NCBI and Uniprot Product Information

• NCBI GI #: 40255013
• NCBI GeneID: 4680
• NCBI Accession #: NP_002474.3
• NCBI GenBank Nucleotide #: NM_002483.5
• UniProt Accession #: P40199; Q13774; Q14920; Q53XP7
• Molecular Weight: 37,195 Da
• NCBI Official Full Name: carcinoembryonic antigen-related cell adhesion molecule 6
• NCBI Official Synonym Full Names: carcinoembryonic antigen related cell adhesion molecule 6
• NCBI Official Symbol: CEACAM6
• NCBI Official Synonym Symbols: NCA; CEAL; CD66c
• NCBI Protein Information: carcinoembryonic antigen-related cell adhesion molecule 6
• UniProt Protein Name: Carcinoembryonic antigen-related cell adhesion molecule 6
• Protein Family: Carcinoembryonic antigen-related cell adhesion molecule
• UniProt Gene Name: CEACAM6
• UniProt Synonym Gene Names: NCA

NCBI Description

This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]

Uniprot Description

CEACAM6: a glycosylphosphatidylinositol(GPI)-linked glycoprotein implicated in a variety of human cancers. Expressed on epithelial cells of various tissues, especially colon, lung, pancreas, trachea, and bone marrow. Participates in innate immune defense, cell proliferation and differentiation. Expressed at high levels in gastrointestinal tract, pancreatic and lung tumors. CEACAM6 promotes tumor angiogenesis in gastric cancer. May enhance invasiveness and metastatic potential in gastric and pancreatic cancer by promoting EMT via PI3K/AKT signaling. Upregulated by the pro-inflammatory cytokine IL-6. Belongs to the immunoglobulin superfamily/CEA family.

Protein type: Membrane protein, GPI anchor; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane

Molecular Function: protein binding

Biological Process: cell-cell signaling; leukocyte migration; positive regulation of cell migration; positive regulation of cell proliferation; signal transduction