Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 821080(CDKN2AIP Antibody) at dilution 1/40. (Original magnification: ×200))
Rabbit anti-Human CDKN2AIP Polyclonal Antibody | anti-CDKN2AIP antibody
CDKN2AIP Rabbit pAb
Gene Names
CDKN2AIP; CARF
Reactivity
Human
Applications
ELISA, Immunohistochemistry
Purity
Affinity purified
Synonyms
CDKN2AIP; Polyclonal Antibody; CDKN2AIP Rabbit pAb; CDKN2A interacting protein; anti-CDKN2AIP antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Ubiquitously expressed.
Purity/Purification
Affinity purified
Form/Format
pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Applicable Applications for anti-CDKN2AIP antibody
ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P)
Application Notes
ELISA: 1:1000-1:5000
IHC: 1:50-1:200
IHC: 1:50-1:200
Immunogen
Fusion protein of human CDKN2AIP
Conjugation
Unconjugated
Molecular Function
Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence.
Modification
Unmodified
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 821080(CDKN2AIP Antibody) at dilution 1/40. (Original magnification: ×200))
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 821080(CDKN2AIP Antibody) at dilution 1/40. (Original magnification: ×200))
Related Product Information for anti-CDKN2AIP antibody
CDKN2AIP (CDKN2A-interacting protein), also known as CARF, is a 580 amino acid protein that activates p53 via p14 ARF (alternate reading frame)-dependent and independent pathways. CDKN2AIP-dependent activation of p53, a protein that up-regulates growth arrest and apoptosis-related genes in response to stress signals, leads to an enhancement of p53 function. Expression levels of CDKN2AIP and p53 show an inverse relationship that is caused by a negative-feedback control via a proteasome-mediated degradation pathway. CDKN2AIP is expressed ubiquitously across tissue samples and, along with p14 ARF, is localized to the perinucleolar region within the nucleus.
Product Categories/Family for anti-CDKN2AIP antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
580
NCBI Official Full Name
CDKN2A-interacting protein
NCBI Official Synonym Full Names
CDKN2A interacting protein
NCBI Official Symbol
CDKN2AIP
NCBI Official Synonym Symbols
CARF
NCBI Protein Information
CDKN2A-interacting protein; collaborator of ARF; collaborates/cooperates with ARF (alternate reading frame) protein
UniProt Protein Name
CDKN2A-interacting protein
Protein Family
UniProt Gene Name
CDKN2AIP
UniProt Synonym Gene Names
CARF
UniProt Entry Name
CARF_HUMAN
Uniprot Description
CDKN2AIP: co-localizes and interacts with p14ARF in the nucleolus. Co-regulated with ARF and cooperates with it in activating p53.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 4q35.1
Cellular Component: nucleoplasm; granular component; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; RNA binding; p53 binding
Biological Process: positive regulation of signal transduction; regulation of protein stability; negative regulation of cell growth; response to DNA damage stimulus; positive regulation of cell growth
Research Articles on CDKN2AIP
Similar Products
Product Notes
The CDKN2AIP cdkn2aip (Catalog #AAA4757835) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CDKN2AIP Rabbit pAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CDKN2AIP can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P). ELISA: 1:1000-1:5000 IHC: 1:50-1:200. Researchers should empirically determine the suitability of the CDKN2AIP cdkn2aip for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CDKN2AIP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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