Rabbit anti-Human CDKL3 Polyclonal Antibody | anti-CDKL3 antibody

CDKL3 Antibody

Cat. Num. AAA9406059

• Gene Names: CDKL3; NKIAMRE
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: CDKL3; Polyclonal Antibody; CDKL3 Antibody; Cyclin-dependent kinase-like 3; EC 2.7.11.22; Serine/threonine protein kinase NKIAMRE; NKIAMRE; anti-CDKL3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total CDKL3 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 592

• Applicable Applications for anti-CDKL3 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:50~1:100
• Immunogen Type: Peptide
• Immunogen Description: Synthesized peptide derived from internal of human CDKL3.
• Target Name: CDKL3
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue, using CDKL3 antibody.)

Related Product Information for anti-CDKL3 antibody

The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms.Midmer M., Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.The MGC Project Team, Genome Res. 14:2121-2127(2004).Greenman C., Nature 446:153-158(2007).

Product Categories/Family for anti-CDKL3 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 166064027
• NCBI GeneID: 51265
• NCBI Accession #: NP_001107047.1
• NCBI GenBank Nucleotide #: NM_001113575.1
• UniProt Accession #: Q8IVW4; Q9P114; D3DQA0; D3DQA1
• Molecular Weight: 51,566 Da
• NCBI Official Full Name: cyclin-dependent kinase-like 3 isoform 1
• NCBI Official Synonym Full Names: cyclin-dependent kinase-like 3
• NCBI Official Symbol: CDKL3
• NCBI Official Synonym Symbols: NKIAMRE
• NCBI Protein Information: cyclin-dependent kinase-like 3
• UniProt Protein Name: Cyclin-dependent kinase-like 3
• Protein Family: Cyclin-dependent kinase
• UniProt Gene Name: CDKL3
• UniProt Synonym Gene Names: NKIAMRE
• UniProt Entry Name: CDKL3_HUMAN

NCBI Description

The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

CDKL3: a protein kinase of the CDKL family. Absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. The function of this gene has not yet been determined.

Protein type: EC 2.7.11.22; Cell cycle regulation; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CMGC group; CDKL family

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: cytoplasm; nucleus

Molecular Function: cyclin-dependent protein kinase activity; ATP binding; protein kinase activity

Biological Process: regulation of cell cycle; protein modification process; negative regulation of axon extension; positive regulation of dendrite morphogenesis; protein amino acid phosphorylation