Western Blot (WB)
(Western blot analysis of CDK10 antibody (N-term) pre-incubated with (Lane1) and without (Lane 2) blocking peptide in A375 cell line lysate. CDK10 (arrow) was detected using the purified Pab.)
Rabbit CDK10 Polyclonal Antibody | anti-CDK10 antibody
CDK10 Antibody (N-term)
Western Blot (WB)
(Western blot analysis of CDK10 antibody (N-term) pre-incubated with (Lane1) and without (Lane 2) blocking peptide in A375 cell line lysate. CDK10 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of CDK10 antibody (N-term) pre-incubated with (Lane1) and without (Lane 2) blocking peptide in A375 cell line lysate. CDK10 (arrow) was detected using the purified Pab.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
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Grana, X., et al., Oncogene 9(7):2097-2103 (1994).
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Sherr, C. Science 274:1672 (1996)
Kamb A. TIG 11:136 (1995)
Zhang, H. et al, Cell 82, 915 (1995)
Parge, HE. et al., Science 262, 387 (1993)
Hershko, A. et al., Ann. Rev. Biochem. 61, 761 (1992)
Peters, JM. Curr. Biol. 10, 759 (1998)
Skowyra, D. etal., Cell 91, 209 (1997)
Ganoth D. et al., Nature Cell Biol. 3, 321-324 (2001)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Uniprot Description
CDK10: a CMGC kinase of the CDK family. Plays a role in cellular proliferation. Its function is limited to cell cycle G2-M phase. At least three alternatively spliced isoforms have been reported, two of which contain multiple non-AUG translation initiation sites.
Protein type: EC 2.7.11.22; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; Kinase, protein; Cell cycle regulation; CMGC group; CDK family; CDK/CDK10 subfamily; CDK10 subfamily
Chromosomal Location of Human Ortholog: 16q24
Molecular Function: protein binding; cyclin-dependent protein kinase activity; ATP binding
Biological Process: negative regulation of cell proliferation; traversing start control point of mitotic cell cycle; positive regulation of MAPKKK cascade; protein amino acid phosphorylation
Research Articles on CDK10
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Product Notes
The CDK10 cdk10 (Catalog #AAA9203532) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-32. The CDK10 Antibody (N-term) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's CDK10 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the CDK10 cdk10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CDK10, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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