Rabbit anti-Human, Mouse CDIP Polyclonal Antibody | anti-C16orf5 antibody

CDIP Antibody

Cat. Num. AAA151219

• Gene Names: CDIP1; I1; CDIP; LITAFL; C16orf5
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: CDIP Antibody is affinity chromatography purified via peptide column.
• Synonyms: CDIP; Polyclonal Antibody; CDIP Antibody; I1; LITAFL; C16orf5; Cell death-inducing p53-target protein 1; Cell death involved p53-target; chromosome 16 open reading frame 5; anti-C16orf5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: CDIP Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 208

• Applicable Applications for anti-C16orf5 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: CDIP antibody can be used for detection of CDIP by Western blot at 0.25 - 0.5 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: CDIP antibody was raised against a 19 amino acid synthetic peptide near the center of human CDIP.
• Buffer: CDIP Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: CDIP antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of CDIP in human brain lysate with CDIP antibody at (A) 0.25 and (B) 0.5 μg/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of CDIP in mouse brain tissue with CDIP antibody at 2.5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of CDIP1 in mouse brain tissue with CDIP1 antibody at 20 μg/mL.)

Related Product Information for anti-C16orf5 antibody

CDIP Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induced apoptosis in transfected cells while siRNA suppression of caspase-8 mRNA blocked this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through extrinsic cell death pathway. CDIP may thus represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist.

NCBI and Uniprot Product Information

• NCBI GI #: 118344450
• NCBI GeneID: 29965
• NCBI Accession #: NP_037531
• NCBI GenBank Nucleotide #: NM_013399.2
• UniProt Accession #: Q9H305; Q96ID8; Q9H0Q4; Q9P112; A8K7M1; B4DFU1; B4DY75; D3DUD6
• Molecular Weight: 13,763 Da
• NCBI Official Full Name: cell death-inducing p53-target protein 1 isoform a
• NCBI Official Synonym Full Names: cell death-inducing p53 target 1
• NCBI Official Symbol: CDIP1
• NCBI Official Synonym Symbols: I1; CDIP; LITAFL; C16orf5
• NCBI Protein Information: cell death-inducing p53-target protein 1; LITAF-like protein; transmembrane protein I1; cell death inducing protein; cell death-inducing protein; cell death involved p53-target; lipopolysaccharide-induced tumor necrosis factor-alpha-like protein
• UniProt Protein Name: Cell death-inducing p53-target protein 1
• UniProt Gene Name: CDIP1
• UniProt Synonym Gene Names: C16orf5; CDIP; LITAFL
• UniProt Entry Name: CDIP1_HUMAN

Uniprot Description

CDIP: Belongs to the LITAF family.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: nucleus

Biological Process: tumor necrosis factor-mediated signaling pathway; apoptosis; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis