Rabbit anti-Human Cdc37 Polyclonal Antibody | anti-CDC37 antibody

CDC37 Antibody: ATTO 488

Cat. Num. AAA805455

• Gene Names: CDC37; P50CDC37
• Reactivity: Human
• Applications: Western Blot
• Synonyms: Cdc37; Polyclonal Antibody; CDC37 Antibody: ATTO 488; anti-CDC37 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Form/Format: Protein A Purified
• Concentration: 1.68mg/mL (varies by lot)
• Sequence Length: 378

• Applicable Applications for anti-CDC37 antibody: Western Blot (WB)
• Conjugate: ATTO 488
• Storage Buffer: PBS, 50% glycerol, 0.09% sodium azide
• Preparation and Storage: -20 degree C

Western Blot (WB)

(Western blot analysis of Human Cervical cancer cell line (HeLa) lysate showing detection of CDC37 protein using Rabbit Anti-CDC37 Polyclonal Antibody (SPC-142). Primary Antibody: Rabbit Anti-CDC37 Polyclonal Antibody (SPC-142) at 1:2000.)

Related Product Information for anti-CDC37 antibody

Background Info: Detects ~44.5kDa.

Scientific Background: Hsp90 co-chaperone Cdc37 is a protein that is encoded by the CDC37 gene. It has been found to form complexes with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF1, MOK and elF-2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases (1, 2). CDC37 is necessary for maintaining prostate tumor cell growth and represents a novel target in the exploration for multi-targeted therapies (3, 4).

Product Categories/Family for anti-CDC37 antibody

Heat Shock

References

1. Dai K, Kobayashi R., Beach D. (1996) J Biol Chem. 271(36): 22030-22034. 2. Stepanova L, Leng X., Parker S.B., Harper J.W. (1996) Genes Dev. 10(12): 1491-1502. 3. Kimura Y., et al. (1997) Genes Dev. 11(14): 1775- 1185. 4. Gray P.J., et al. (2008) Nat Rev Cancer. 8(7): 491- 495.

NCBI and Uniprot Product Information

• NCBI GI #: 5901922
• NCBI GeneID: 11140
• NCBI Accession #: NP_008996.1
• NCBI GenBank Nucleotide #: NM_007065.3
• UniProt Accession #: Q16543; Q53YA2
• Molecular Weight: 44,468 Da
• NCBI Official Full Name: hsp90 co-chaperone Cdc37
• NCBI Official Synonym Full Names: cell division cycle 37
• NCBI Official Symbol: CDC37
• NCBI Official Synonym Symbols: P50CDC37
• NCBI Protein Information: hsp90 co-chaperone Cdc37; cell division cycle 37 homolog; CDC37 cell division cycle 37 homolog; hsp90 chaperone protein kinase-targeting subunit; CDC37 (cell division cycle 37, S. cerevisiae, homolog)
• UniProt Protein Name: Hsp90 co-chaperone Cdc37
• Protein Family: Hsp90 co-chaperone
• UniProt Gene Name: CDC37
• UniProt Synonym Gene Names: CDC37A
• UniProt Entry Name: CDC37_HUMAN

NCBI Description

The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]

Uniprot Description

CDC37: a molecular chaperone that functions in cell signal transduction. Forms complexes with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. Also interacts with androgen receptor. It is thought to play a critical role in directing Hsp90 to its target kinases.

Protein type: Chaperone

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: protein complex; cytoplasm; cytosol

Molecular Function: protein kinase B binding; protein binding; heat shock protein binding; chaperone binding; unfolded protein binding; mitogen-activated protein kinase kinase kinase binding; Hsp90 protein binding; kinase binding

Biological Process: protein stabilization; protein folding; regulation of cyclin-dependent protein kinase activity; protein targeting