Rabbit CD96 Polyclonal Antibody | anti-CD96 antibody

Human CD96 Affinity Purified Polyclonal

Cat. Num. AAA551224

• Gene Names: CD96; TACTILE
• Synonyms: CD96; Polyclonal Antibody; Human CD96 Affinity Purified Polyclonal; RAA05601; polyclonal; anti-CD96 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Isotype: Rabbit IgG

• Application Notes: Western Blot Concentration: 0.1-0.2 ug/ml; Western Blot Limit: 0.5 ng/lane; ELISA Concentration: 0.1-0.2 ug/ml; ELISA Limit: 2 pg/well
• Preparation and Storage: This antibody can be stored in working aliquots at 2C - 8C for one month without detectable loss of activity. The antibody is stable for at least 1 year from date of receipt at -20C.; ; ; Avoid repeated freeze/thaw cycles.

Product Categories/Family for anti-CD96 antibody

Antigen affinity Polyclonals

NCBI and Uniprot Product Information

• NCBI GI #: 119600104
• NCBI GeneID: 10225
• UniProt Accession #: P40200; Q5JPB3
• Molecular Weight: 65,634 Da
• NCBI Official Full Name: CD96 antigen, isoform CRA_c
• NCBI Official Synonym Full Names: CD96 molecule
• NCBI Official Symbol: CD96
• NCBI Official Synonym Symbols: TACTILE
• NCBI Protein Information: T-cell surface protein tactile; CD96 antigen; cell surface antigen CD96; T cell activation, increased late expression; t cell-activated increased late expression protein
• UniProt Protein Name: T-cell surface protein tactile
• Protein Family: T-cell surface protein tactile
• UniProt Gene Name: CD96
• UniProt Entry Name: TACT_HUMAN

NCBI Description

The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

CD96: May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation. Defects in CD96 are a cause of C syndrome (CSYN); also called Opitz trigonocephaly syndrome. This syndrome is characterized by trigonocephaly and associated anomalies, such as unusual facies, wide alveolar ridges, multiple buccal frenula, limb defects, visceral anomalies, redundant skin, psychomotor retardation and hypotonia. A chromosomal aberration involving CD96 has been found in a patient with C syndrome. Translocation t(3;18)(q13.13;q12.1). CD96 gene was located at the 3q13.13 breakpoint. Precise structural analysis around the breakpoint showed that the gene was disrupted by the translocation in exon 5, probably leading to premature termination or loss of expression of CD96 protein. No gene was detected at the chromosome 18 breakpoint. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q13.13-q13.2

Cellular Component: integral to plasma membrane; plasma membrane

Biological Process: regulation of immune response; immune response; cell adhesion

Disease: C Syndrome