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Western Blot (WB) (Western Blot analysis of ENTPD1 antibody.)

Rabbit CD39 Polyclonal Antibody | anti-CD39 antibody

CD39 Polyclonal Antibody

Gene Names
ENTPD1; CD39; SPG64; ATPDase; NTPDase-1
Reactivity
Human, Mouse, Rat
Applications
Western Blot
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
CD39; Polyclonal Antibody; CD39 Polyclonal Antibody; SPG64; ATPDase; NTPDase-1; anti-CD39 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
CD39 polyclonal antibody detects endogenous levels of CD39 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
517
Applicable Applications for anti-CD39 antibody
Western Blot (WB)
Application Notes
WB: 1:200-1:1000
Immunogen
A synthetic peptide of human ENTPD1.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of ENTPD1 antibody.)

Western Blot (WB) (Western Blot analysis of ENTPD1 antibody.)
Related Product Information for anti-CD39 antibody
CD39 is also weakly expressed on granulocytes. CD39 has homology to the Nmyc family of proteins and was recently cloned. CD39 can hydrolyze both nucleoside triphosphates and diphosphates. CD39 is the dominant ecto nucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type 2 purinergic (P2) G protein coupled receptors (GPCRs). CD39 transgenic mice exhibit impaired platelet aggregation, prolonged bleeding times, and resistance to systemic thromboembolism. There is a correlation between ATP hydrolysis and triglycerides in patients with chronic heart disease, suggesting a relationship between ATP diphosphohydrolase and thrombogenesis.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
953
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~ 65kDa
NCBI Official Full Name
ectonucleoside triphosphate diphosphohydrolase 1 isoform 2
NCBI Official Synonym Full Names
ectonucleoside triphosphate diphosphohydrolase 1
NCBI Official Symbol
ENTPD1
NCBI Official Synonym Symbols
CD39; SPG64; ATPDase; NTPDase-1
NCBI Protein Information
ectonucleoside triphosphate diphosphohydrolase 1
UniProt Protein Name
Ectonucleoside triphosphate diphosphohydrolase 1
UniProt Gene Name
ENTPD1
UniProt Synonym Gene Names
CD39; NTPDase 1; Ecto-ATPDase 1
UniProt Entry Name
ENTP1_HUMAN

NCBI Description

The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Uniprot Description

ENTPD1: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. Belongs to the GDA1/CD39 NTPase family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Nucleotide Metabolism - purine; EC 3.6.1.5; Extracellular matrix; Nucleotide Metabolism - pyrimidine; Membrane protein, multi-pass; Hydrolase

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: membrane; integral to plasma membrane; plasma membrane; basal lamina

Molecular Function: protein binding; nucleoside-diphosphatase activity; nucleoside-triphosphatase activity; ATP binding

Biological Process: platelet activation; G-protein coupled receptor protein signaling pathway; purine ribonucleoside diphosphate catabolic process; cell adhesion; blood coagulation

Disease: Spastic Paraplegia 64, Autosomal Recessive

Research Articles on CD39

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Product Notes

The CD39 entpd1 (Catalog #AAA3008536) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CD39 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CD39 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:200-1:1000. Researchers should empirically determine the suitability of the CD39 entpd1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD39, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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