Immunohistochemistry
(Immunohistochemical analysis of mouse CD31 expression in FFPE vascular endothelial melanoma cell. Used at a primary antibody dilution of 1:200, DAB chomogen substrate.)
CD31 (PECAM1) Polyclonal Antibody | anti-CD31 antibody
Rabbit anti CD31 (PECAM1) Polyclonal
Western blot: Use at a concentration range of 2-10 ug/ml.
IHC: A suitable range of concentrations of this antibody for IHC is 2-10 ug/ml.
Avoid repeated freeze/thaw cycles.
Immunohistochemistry
(Immunohistochemical analysis of mouse CD31 expression in FFPE vascular endothelial melanoma cell. Used at a primary antibody dilution of 1:200, DAB chomogen substrate.)
Immunohistochemistry
(Immunohistochemical analysis of mouse CD31 expression in FFPE vascular endothelial melanoma cell. Used at a primary antibody dilution of 1:200, DAB chomogen substrate.)
Immunohistochemical
(Immunohistochemical analysis of CD31-positive microvessles in FFPE Human malignant melanoma cell line A375. Used at a primary antibody dilution of 1:200, DAB chomogen substrate.)
Immunohistochemical
(Immunohistochemical analysis of CD31-positive microvessles in FFPE Human malignant melanoma cell line A375. Used at a primary antibody dilution of 1:200, DAB chomogen substrate.)
• cd38/CD31, the ccl3 and ccl4 chemokines, and cd49d/vascular cell adhesion molecule-1 are interchained by sequential events sustaining chronic lymphocytic leukemia cell survival .Cancer Res., May 2009; 69: 4001 - 4009.
• circulating monocytes expressing CD31: implications for acute and chronic angiogenesis .Am. J. Pathol., May 2009; 174: 1972 - 1980.
• il-7 sustains CD31 expression in human naive cd4+ t cells and preferentially expands the CD31+ subset in a pi3k-dependent manner .Blood, Mar 2009; 113: 2999 - 3007.
• transcriptional profiling of CD31+ cells isolated from murine embryonic stem cells .Genes Cells, Feb 2009; 14: 243 - 260.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]
Uniprot Description
PECAM-1: a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Plays a role in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, cell migration, negative regulation of immune cell signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. Undergoes alternative splicing, generating multiple isoforms in vascular beds of various tissues.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17q23.3
Cellular Component: extracellular space; platelet alpha granule membrane; plasma membrane; integral to membrane; cell junction
Molecular Function: protein binding
Biological Process: platelet activation; extracellular matrix organization and biogenesis; platelet degranulation; diapedesis; cell recognition; signal transduction; blood coagulation; cell adhesion; leukocyte migration; phagocytosis
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Product Notes
The CD31 pecam1 (Catalog #AAA551038) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti CD31 (PECAM1) Polyclonal reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CD31 (PECAM1) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), IHC (Immunohistochemistry), ELISA (EIA). ELISA: Use at a concentration range of 1-2ug/ml. Western blot: Use at a concentration range of 2-10 ug/ml. IHC: A suitable range of concentrations of this antibody for IHC is 2-10 ug/ml. Researchers should empirically determine the suitability of the CD31 pecam1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD31 (PECAM1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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