Rabbit anti-Human, Mouse CD3 Gamma Polyclonal Antibody | anti-CD3 antibody

CD3 Gamma Antibody FITC-Conjugated

Cat. Num. AAA541213

• Gene Names: CD3G; T3G; IMD17; CD3-GAMMA
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Synonyms: CD3 Gamma; Polyclonal Antibody; CD3 Gamma Antibody FITC-Conjugated; CD3 gamma; CD3g; CD3g antigen gamma polypeptide (TiT3 complex); CD3g antigen gamma polypeptide; CD3g molecule gamma (CD3 TCR complex); T-cell receptor T3 gamma chain; T-cell surface glycoprotein CD3 gamma chain; T3G antibody; anti-CD3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Form/Format: FITC-Conjugated
• Concentration: 0.55-0.75 ug/ul in antibody stabilization buffer (varies by lot)
• Sequence Length: 182

• Applicable Applications for anti-CD3 antibody: ELISA (EIA), IMM, Western Blot (WB)
• Application Notes: Dot Blot: 1:10,000; ELISA: 1:10,000; Immunoprecipitation: 1:150; Western Blot: 1:500
• Immunogen: Synthetic peptide taken within amino acid region 131-181 on human T-cell surface glycoprotein CD3 gamma protein.
• Molecular Function: Protein heterodimerization activity; T cell receptor binding; Receptor signaling complex scaffold activity; Transmembrane signaling receptor activity
• Structure: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.
• Subcellular Location: Membrane; Single-pass type I membrane protein
• Preparation and Storage: -20 degree C for long term storage

Related Product Information for anti-CD3 antibody

FITC-Conjugated T-cell surface glycoprotein CD3 gamma chain Antibody
The CD3 complex mediates signal transduction.

NCBI and Uniprot Product Information

• NCBI GI #: 4557429
• NCBI GeneID: 917
• NCBI Accession #: NP_000064.1
• NCBI GenBank Nucleotide #: NM_000073.2
• UniProt Accession #: P09693; Q2HIZ6
• Molecular Weight: 20,469 Da
• NCBI Official Full Name: T-cell surface glycoprotein CD3 gamma chain
• NCBI Official Synonym Full Names: CD3g molecule
• NCBI Official Symbol: CD3G
• NCBI Official Synonym Symbols: T3G; IMD17; CD3-GAMMA
• NCBI Protein Information: T-cell surface glycoprotein CD3 gamma chain
• UniProt Protein Name: T-cell surface glycoprotein CD3 gamma chain
• UniProt Gene Name: CD3G
• UniProt Synonym Gene Names: T3G
• UniProt Entry Name: CD3G_HUMAN

NCBI Description

The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]

Uniprot Description

CD3G: The CD3 complex mediates signal transduction.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: alpha-beta T cell receptor complex; integral to plasma membrane; plasma membrane; T cell receptor complex

Molecular Function: protein heterodimerization activity; receptor signaling complex scaffold activity; T cell receptor binding; transmembrane receptor activity

Biological Process: cell surface receptor linked signal transduction; establishment and/or maintenance of cell polarity; protein complex assembly; protein transport; regulation of immune response; T cell activation; T cell costimulation; T cell receptor signaling pathway

Disease: Immunodeficiency 17