Rabbit anti-Human CD226 Polyclonal Antibody | anti-CD226 antibody

CD226, CT (CD226, DNAM1, CD226 antigen, DNAX accessory molecule 1, CD226) (MaxLight 405)

Cat. Num. AAA6282965

• Gene Names: CD226; PTA1; DNAM1; DNAM-1; TLiSA1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: CD226; Polyclonal Antibody; CT (CD226; DNAM1; CD226 antigen; DNAX accessory molecule 1; CD226) (MaxLight 405); anti-CD226 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CD226.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.

• Applicable Applications for anti-CD226 antibody: FLISA, Western Blot (WB)
• Application Notes: WB: 1:1000; Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 307-335 in the C-terminal region of human CD226, UniProt Accession #NP_006557.2; Q15762.
• Conjugate: MaxLight405
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in Jurkat cell line lysates (35ug/lane) using 033480. This demonstrates that 033480 detected the CD226 protein (arrow).)

Product Categories/Family for anti-CD226 antibody

Antibodies; CD Markers

References

1. Lofgren, S.E., et al., Arthritis Rheum. 62(11): 3404-3414 (2010). 2. Carlsten, M., et al., Leukemia 24(9): 1607-1616 (2010). 3. Plant, D., et al., Ann. Rheum. Dis. 69(8): 1548-1553 (2010). 4. Alcina, A., et al., Genes Immun. 11(5): 439-445 (2010). 5. Jian, J.L., et al., J. Biol. Chem. 281(39): 28, 731-28, 736 (2006).

NCBI and Uniprot Product Information

• NCBI GI #: 171460997
• NCBI GeneID: 10666
• NCBI Accession #: NP_006557.2
• NCBI GenBank Nucleotide #: NM_006566.2
• UniProt Accession #: Q15762; B2R818
• Molecular Weight: 38,614 Da
• NCBI Official Full Name: CD226 antigen
• NCBI Official Synonym Full Names: CD226 molecule
• NCBI Official Symbol: CD226
• NCBI Official Synonym Symbols: PTA1; DNAM1; DNAM-1; TLiSA1
• NCBI Protein Information: CD226 antigen; adhesion glycoprotein; DNAX accessory molecule 1; DNAX accessory molecule-1; platelet and T cell activation antigen 1; T lineage-specific activation antigen 1 antigen
• UniProt Protein Name: CD226 antigen
• Protein Family: CD226 antigen
• UniProt Gene Name: CD226
• UniProt Synonym Gene Names: DNAM1; DNAM-1
• UniProt Entry Name: CD226_HUMAN

NCBI Description

This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. [provided by RefSeq, Jul 2008]

Uniprot Description

DNAM-1: Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.

Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q22.3

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; external side of plasma membrane; lipid raft

Molecular Function: integrin binding; protein binding; cell adhesion molecule binding; protein kinase binding

Biological Process: regulation of immune response; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of immunoglobulin mediated immune response; cytokine production; cell recognition; cell adhesion; positive regulation of natural killer cell mediated cytotoxicity; signal transduction; positive regulation of mast cell activation