Western Blot (WB)
(Anti-CD1a antibody, MBS176172, Western blottingAll lanes: Anti CD1a (MBS176172) at 0.5ug/mlLane 1: JURKAT Whole Cell Lysate at 40ugLane 2: SW620 Whole Cell Lysate at 40ugLane 3: CEM Whole Cell Lysate at 40ugPredicted bind size: 37KDObserved bind size: 37KD)
Rabbit anti-Human CD1a Polyclonal Antibody | anti-CD1A antibody
Anti-CD1a antibody
Western Blot (WB)
(Anti-CD1a antibody, MBS176172, Western blottingAll lanes: Anti CD1a (MBS176172) at 0.5ug/mlLane 1: JURKAT Whole Cell Lysate at 40ugLane 2: SW620 Whole Cell Lysate at 40ugLane 3: CEM Whole Cell Lysate at 40ugPredicted bind size: 37KDObserved bind size: 37KD)
Western Blot (WB)
(Anti-CD1a antibody, MBS176172, Western blottingAll lanes: Anti CD1a (MBS176172) at 0.5ug/mlLane 1: JURKAT Whole Cell Lysate at 40ugLane 2: SW620 Whole Cell Lysate at 40ugLane 3: CEM Whole Cell Lysate at 40ugPredicted bind size: 37KDObserved bind size: 37KD)
Background: CD1A(Thymocyte antigen CD1A) also known as CD1, is a human protein encoded by the CD1A gene. CD1A is 1 of 5 distinct CD1 genes that are variably conserved in different mammalian species. This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex(MHC) proteins and form heterodimers with beta-2-microglobulin.The CD1A gene is mapped on 1q23.1. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. CD1A is concentrated in the early or recycling endosome. Moody et al.(2004) reported that CD1A presents to T cells a family of previously unknown lipopeptides from Mycobacterium tuberculosis, named didehydroxymycobactins because of their structural relation to mycobactin siderophores. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Apolipoprotein E(107741) binds lipid antigens and delivers them by receptor-mediated uptake into endosomal compartments containing CD1 in antigen-presenting cells.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
CD1A: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q23.1
Cellular Component: integral to plasma membrane; plasma membrane; endosome membrane
Molecular Function: protein binding; beta-2-microglobulin binding; exogenous lipid antigen binding; endogenous lipid antigen binding
Biological Process: antigen processing and presentation, exogenous lipid antigen via MHC class Ib; immune response
Research Articles on CD1A
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Product Notes
The CD1A cd1a (Catalog #AAA176172) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CD1a antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD1a can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the CD1A cd1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD1a, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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