Sheep anti-Human CD109 Polyclonal Antibody | anti-CD109 antibody

CD109

Cat. Num. AAA614563

• Gene Names: CD109; CPAMD7; FLJ38569; FLJ41966; RP11-525G3.1; DKFZp762L1111
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by human CD109 affinity chromatography.
• Synonyms: CD109; Polyclonal Antibody; Anti -CD109; anti-CD109 antibody

• Host: Sheep
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CD109.
• Purity/Purification: Affinity Purified; Purified by human CD109 affinity chromatography.
• Form/Format: Supplied as a lyophilized powder in PBS, 5% trehalose. Reconstitute with 200ul 40-50% glycerol, PBS.

• Applicable Applications for anti-CD109 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Direct ELISA and Western Blot.; Dilution: Direct ELISA: 0.5-1ug/mL detection limit for rhCD109 ~ 0.3ng/well.; Western Blot: 0.1-0.2ug/mL detection limit for rhCD109 ~ 10ng/lane under non-reducing and reducing conditions.
• Immunogen: CD109 NS0-derived rhCD109.
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-CD109 antibody

Antibodies; Abs to CD Markers

NCBI and Uniprot Product Information

• NCBI GI #: 227430303
• NCBI GeneID: 135228
• NCBI Accession #: NP_001153060.1
• NCBI GenBank Nucleotide #: NM_001159588.1
• UniProt Accession #: Q5XUM6; Q5XUM8; Q5XUN0; Q5XUN1; Q6YHK3
• Molecular Weight: 3,741 Da
• NCBI Official Full Name: CD109 antigen isoform 3
• NCBI Official Synonym Full Names: CD109 molecule
• NCBI Official Symbol: CD109
• NCBI Official Synonym Symbols: CPAMD7; FLJ38569; FLJ41966; RP11-525G3.1; DKFZp762L1111
• NCBI Protein Information: CD109 antigen; p180; r150; OTTHUMP00000016748; Gov platelet alloantigens; activated T-cell marker CD109; platelet-specific Gov antigen; 150 kDa TGF-beta-1-binding protein; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7
• UniProt Protein Name: CD109
• Protein Family: CD109 antigen
• UniProt Entry Name: Q5XUM6_HUMAN

NCBI Description

This gene encodes a member of the alpha2-macroglobulin/complement superfamily. The encoded GPI-linked glycoprotein is found on the cell surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signaling of transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene.

Uniprot Description

CD109: Modulates negatively TGFB1 signaling in keratinocytes. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 6q13

Cellular Component: extracellular space; cell surface; plasma membrane

Molecular Function: serine-type endopeptidase inhibitor activity; transforming growth factor beta binding

Biological Process: hair follicle development; negative regulation of protein amino acid phosphorylation; negative regulation of transforming growth factor beta receptor signaling pathway; regulation of keratinocyte differentiation