CD109 recombinant protein

Recombinant Human CD109 protein, C-His Tag

Cat. Num. AAA1560567

• Gene Names: CD109; CPAMD7; RP11-525G3.1
• Purity: >90% as determined by SDS-PAGE
• Synonyms: CD109; Recombinant Human CD109 protein; C-His Tag; CD109 recombinant protein

• Host: Mammalian cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Tag: C-His Tag
• Species: Homo sapiens (Human)
• Endotoxin Level: <1.0EU per ug of the protein as determined by the LAL method.
• Protein Construction: A DNA sequence encoding the human CD109 (Met1-Ala1420) was fused with the C-terminal His Tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

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Product Categories/Family for CD109 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 227430303
• NCBI GeneID: 135228
• NCBI Accession #: NP_001153060.1
• NCBI GenBank Nucleotide #: NM_001159588.1
• UniProt Accession #: Q6YHK3; Q0P6K7; Q5SYA8; Q5XUM7; Q5XUM9; Q6MZI7; Q8N3A7; Q8N915; Q8TDJ2; A5YKK4; B2R948; B3KW25
• Molecular Weight: 161,689 Da
• NCBI Official Full Name: CD109 antigen isoform 3
• NCBI Official Synonym Full Names: CD109 molecule
• NCBI Official Symbol: CD109
• NCBI Official Synonym Symbols: CPAMD7; RP11-525G3.1
• NCBI Protein Information: CD109 antigen; p180; r150; Gov platelet alloantigens; activated T-cell marker CD109; platelet-specific Gov antigen; 150 kDa TGF-beta-1-binding protein; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7
• UniProt Protein Name: CD109 antigen
• Protein Family: CD109 antigen
• UniProt Gene Name: CD109
• UniProt Synonym Gene Names: CPAMD7
• UniProt Entry Name: CD109_HUMAN

NCBI Description

This gene encodes a member of the alpha2-macroglobulin/complement superfamily. The encoded GPI-linked glycoprotein is found on the cell surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signaling of transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]

Uniprot Description

CD109: Modulates negatively TGFB1 signaling in keratinocytes. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 6q13

Cellular Component: extracellular space; cell surface; plasma membrane

Molecular Function: serine-type endopeptidase inhibitor activity; transforming growth factor beta binding

Biological Process: hair follicle development; negative regulation of protein amino acid phosphorylation; negative regulation of transforming growth factor beta receptor signaling pathway; regulation of keratinocyte differentiation