Immunohistochemistry (IHC)
Rabbit anti-Mouse, Rat CCR2 Polyclonal Antibody | anti-Ccr2 antibody
Anti-CCR2 Antibody
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
IHC-P (Embedded Section): 0.5-1ug/ml (Mouse, Rat)
Tested Species: In-house tested species with positive results.
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Western Blot (WB)
(Figure 1. Western blot analysis of Ccr2 using anti-Ccr2 antibody.)
Western Blot (WB)
(Figure 1. Western blot analysis of Ccr2 using anti-Ccr2 antibody.)
Background: C-C chemokine receptor type 2 (CCR2 or CD192 (cluster of differentiation 192) is a protein that in humans is encoded by the CCR2 gene. CCR2 is a chemokine receptor. It is mapped to 9 F4; 9 75.05 cM. The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection.
2. Boring, L., Gosling, J., Cleary, M., Charo, I. F. Decreased lesion formation in CCR2 -/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 394: 894-897, 1998.
3. Daugherty, B. L., Springer, M. S. The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21. Genomics 41: 294-295, 1997.
NCBI and Uniprot Product Information
Uniprot Description
CCR2: a seven transmembrane protein closely related to CCR1. Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. Transduces a signal by increasing the intracellular calcium ions level. Alternative co receptor with CD4 for HIV-1 infection. Two splice-variant isoforms have been described.
Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR
Cellular Component: membrane; integral to plasma membrane; plasma membrane; integral to membrane; external side of plasma membrane
Molecular Function: G-protein coupled receptor activity; signal transducer activity; protein binding; C-C chemokine receptor activity; cytokine binding; chemokine receptor activity
Biological Process: positive regulation of T-helper 1 type immune response; signal transduction; sensory perception of pain; chemotaxis; regulation of cell migration; monocyte chemotaxis; hemopoiesis; angiogenesis; cellular homeostasis; inflammatory response; healing during inflammatory response; positive regulation of tumor necrosis factor biosynthetic process; cytokine and chemokine mediated signaling pathway; humoral immune response; G-protein coupled receptor protein signaling pathway; positive regulation of interferon-gamma production; negative regulation of angiogenesis; negative regulation of T-helper 2 type immune response; positive regulation of interleukin-2 production; cellular defense response; blood vessel remodeling; positive regulation of alpha-beta T cell proliferation; immune response; negative regulation of eosinophil degranulation; positive regulation of T cell activation; positive regulation of T-helper 1 cell differentiation; apoptotic cell clearance; positive regulation of inflammatory response
Research Articles on Ccr2
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Product Notes
The Ccr2 ccr2 (Catalog #AAA1752916) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CCR2 Antibody reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CCR2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. WB: 0.25-0.5ug/ml (Mouse, Rat) IHC-P (Embedded Section): 0.5-1ug/ml (Mouse, Rat) Tested Species: In-house tested species with positive results. Researchers should empirically determine the suitability of the Ccr2 ccr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CCR2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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