Rabbit anti-Human, Rat CCNA1 Polyclonal Antibody | anti-CCNA1 antibody

CCNA1 Polyclonal Antibody

Cat. Num. AAA2566522

• Reactivity: Human, Rat
• Applications: Western Blot
• Purity: Affinity purification
• Synonyms: CCNA1; Polyclonal Antibody; CCNA1 Polyclonal Antibody; CT146; cyclin-A1; anti-CCNA1 antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: 1mg/mL (varies by lot)

• Applicable Applications for anti-CCNA1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant fusion protein of human CCNA1 (NP_0011045151)
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of Rat testis using CCNA1 Polyclonal Antibody at dilution of 1:1000.)

Related Product Information for anti-CCNA1 antibody

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-CCNA1 antibody

Cancer; Cell Biology; Epigenetics and Nuclear Signaling; Polyclonal Antibody

NCBI and Uniprot Product Information

• NCBI GI #: 161377468
• NCBI GeneID: 8900
• NCBI Accession #: NP_001104515.1
• NCBI GenBank Nucleotide #: NM_001111045.1
• UniProt Accession #: P78396; Q5T3V0; Q5U0G2; Q8IY91; B7Z7E3
• Molecular Weight: 53kDa
• NCBI Official Full Name: cyclin-A1 isoform b
• NCBI Official Synonym Full Names: cyclin A1
• NCBI Official Symbol: CCNA1
• NCBI Protein Information: cyclin-A1
• UniProt Protein Name: Cyclin-A1
• Protein Family: Cyclin
• UniProt Gene Name: CCNA1
• UniProt Entry Name: CCNA1_HUMAN

NCBI Description

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

CCNA1: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. Belongs to the cyclin family. Cyclin AB subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Cancer Testis Antigen (CTA); Cell cycle regulation

Chromosomal Location of Human Ortholog: 13q12.3-q13

Cellular Component: nucleoplasm; microtubule cytoskeleton; cytosol

Molecular Function: protein binding; protein kinase binding

Biological Process: G1/S-specific transcription in mitotic cell cycle; mitosis; male meiosis I; cell division; regulation of G2/M transition of mitotic cell cycle; spermatogenesis; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; G2/M transition of mitotic cell cycle; G1/S transition of mitotic cell cycle