Rabbit anti-Human CCN3 / NOV Polyclonal Antibody | anti-CCN3 antibody

Rabbit Polyclonal to Human CCN3 / NOV

Cat. Num. AAA241722

• Gene Names: NOV; CCN3; NOVh; IBP-9; IGFBP9; IGFBP-9
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: CCN3 / NOV; Polyclonal Antibody; Rabbit Polyclonal to Human CCN3 / NOV; Anti-CCN3 / NOV Antibody (C-Terminus) IHC-plus; NOV; CCN3; CCN family member 3; IGFBP9; IBP-9; IGFBP-9; NOVh; IGF-binding protein 9; Nephroblastoma overexpressed; Protein NOV homolog; Human CCN3; anti-CCN3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: synthetic peptide corresponding to C-terminal residues of human NOV protein homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog)
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.01% sodium azide, 50% glycerol.
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 357

• Applicable Applications for anti-CCN3 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA (1 ug/ml), IHC-P (10 ug/ml), WB (1 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: Synthetic peptide from human NOV / CCN3.
• Immunogen Type: Synthetic peptide
• Immunogen: CCN3 / NOV antibody was raised against synthetic peptide from human NOV / CCN3.
• Antigen Modification: C-Terminus
• Preparation and Storage: +4 degree C or -20 degree C, Avoid repeated freezing and thawing.

Immunohistochemistry (IHC)

(Anti-NOV / CCN3 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 4505423
• NCBI GeneID: 4856
• NCBI Accession #: NP_002505.1
• NCBI GenBank Nucleotide #: NM_002514.3
• UniProt Accession #: P48745; Q6I9S3; Q96BY5; Q9UDE4; B2R5X7
• Molecular Weight: 39,162 Da
• NCBI Official Full Name: protein NOV homolog
• NCBI Official Synonym Full Names: nephroblastoma overexpressed
• NCBI Official Symbol: NOV
• NCBI Official Synonym Symbols: CCN3; NOVh; IBP-9; IGFBP9; IGFBP-9
• NCBI Protein Information: protein NOV homolog; CCN family member 3; IGF-binding protein 9; insulin-like growth factor-binding protein 9; nephroblastoma-overexpressed gene protein homolog
• UniProt Protein Name: Protein NOV homolog
• UniProt Gene Name: NOV
• UniProt Synonym Gene Names: CCN3; IGFBP9; NOVH; NovH; IBP-9; IGF-binding protein 9; IGFBP-9
• UniProt Entry Name: NOV_HUMAN

NCBI Description

The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009]

Uniprot Description

NOV: Immediate-early protein likely to play a role in cell growth regulation. Belongs to the CCN family. Expression is down-regulated by WT1. Interacts with FBLN1.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8q24.1

Cellular Component: proteinaceous extracellular matrix; intracellular membrane-bound organelle; cell soma; axon; dendrite

Molecular Function: integrin binding; heparin binding; insulin-like growth factor binding; growth factor activity

Biological Process: cell-cell signaling; regulation of gene expression; regulation of cell growth; cell adhesion; signal transduction