Western Blot (WB)
(CCL4 Antibody (Center) western blot analysis in mouse bladder tissue lysates (15ug/lane).This demonstrates the CCL4 antibody detected CCL4 protein (arrow).)
Rabbit anti-Human, Mouse CCL4 Polyclonal Antibody | anti-CCL4 antibody
CCL4 Antibody (Center)
IHC-P~~1:50~1:100
Western Blot (WB)
(CCL4 Antibody (Center) western blot analysis in mouse bladder tissue lysates (15ug/lane).This demonstrates the CCL4 antibody detected CCL4 protein (arrow).)
Western Blot (WB)
(CCL4 Antibody (Center) western blot analysis in mouse bladder tissue lysates (15ug/lane).This demonstrates the CCL4 antibody detected CCL4 protein (arrow).)
Immunohistochemistry (IHC)
(CCL4 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CCL4 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(CCL4 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CCL4 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Lajoie, J., et al. J. Clin. Immunol. 30(1):90-98(2010)
Colobran, R., et al. Genes Immun. 10(3):254-259(2009)
Shostakovich-Koretskaya, L., et al. AIDS 23(6):679-688(2009)
Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :
NCBI and Uniprot Product Information
NCBI Description
This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. This gene copy contains a non-consensus splice acceptor site at the 3' terminal exon found in other highly similar gene copies, and it thus uses other alternative splice sites for the 3' terminal exon, resulting in multiple transcript variants. [provided by RefSeq, Apr 2014]
Uniprot Description
CCL4: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. Belongs to the intercrine beta (chemokine CC) family.
Protein type: Secreted; Chemokine; Secreted, signal peptide; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: extracellular space; extracellular region
Molecular Function: identical protein binding; protein binding; CCR1 chemokine receptor binding; chemokine activity; cytokine activity; CCR5 chemokine receptor binding
Biological Process: cell-cell signaling; response to virus; response to toxin; establishment and/or maintenance of cell polarity; immune response; positive regulation of calcium-mediated signaling; cell adhesion; signal transduction; inflammatory response; positive regulation of calcium ion transport; cell motility
Research Articles on CCL4
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Product Notes
The CCL4 ccl4 (Catalog #AAA9211087) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 22-48. The CCL4 Antibody (Center) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CCL4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA, Immunohistochemistry-Paraffin (IHC-P). WB~~1:1000 IHC-P~~1:50~1:100. Researchers should empirically determine the suitability of the CCL4 ccl4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CCL4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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