Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded human brain tissue using Girdin antibody. )
Rabbit anti-Human, Mouse CCDC88A Polyclonal Antibody | anti-CCDC88A antibody
CCDC88A Antibody
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded human brain tissue using Girdin antibody. )
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded human brain tissue using Girdin antibody. )
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Uniprot Description
girdin: a ubiquitously expressed actin binding protein that plays an important role in the formation of stress fibers and lamellipodia. Subsequent to phosphorylation by Akt, Girdin accumulates at the leading edge of migrating cells and appears to be crucial for the integrity of the actin cytoskeleton and for cell migration.
Protein type: Actin-binding
Chromosomal Location of Human Ortholog: 2p16.1
Cellular Component: Golgi apparatus; membrane; lamellipodium; endoplasmic reticulum; cytoplasmic membrane-bound vesicle; plasma membrane; cytoplasmic vesicle; cytosol
Molecular Function: protein kinase B binding; protein homodimerization activity; microtubule binding; actin binding; phosphoinositide binding
Biological Process: lamellipodium biogenesis; cell migration; regulation of protein amino acid phosphorylation; TOR signaling pathway; activation of protein kinase B; regulation of actin cytoskeleton organization and biogenesis; DNA replication; regulation of DNA replication; regulation of cell proliferation
Research Articles on CCDC88A
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Product Notes
The CCDC88A ccdc88a (Catalog #AAA7130642) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CCDC88A Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CCDC88A can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). IHC: 1:50-1:100. Researchers should empirically determine the suitability of the CCDC88A ccdc88a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CCDC88A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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