Rabbit anti-Human CC2D1A Polyclonal Antibody | anti-CC2D1A antibody

CC2D1A (AKI1, Coiled-coil and C2 Domain-containing Protein 1A, Akt Kinase-interacting Protein 1, Five Prime Repressor Element Under Dual Repression-binding Protein 1, Putative NF-kappa-B-activating Protein 023N, FLJ20241, FLJ41160) (MaxLight 405)

Cat. Num. AAA6372459

• Gene Names: CC2D1A; MRT3; FREUD-1; Freud-1/Aki1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CC2D1A; Polyclonal Antibody; CC2D1A (AKI1; Coiled-coil and C2 Domain-containing Protein 1A; Akt Kinase-interacting Protein 1; Five Prime Repressor Element Under Dual Repression-binding Protein 1; Putative NF-kappa-B-activating Protein 023N; FLJ20241; FLJ41160) (MaxLight 405); anti-CC2D1A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CC2D1A.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.

• Applicable Applications for anti-CC2D1A antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human CC2D1A, aa1-951 (NP_060191.3).
• Immunogen Sequence: MHKRKGPPGPPGRGAAAARQLGLLVDLSPDGLMIPEDGANDEELEAEFLALVGGQPPALEKLKGKGPLPMEAIEKMASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEVLGEEQKASETPPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPKATSTRAQQQLAFLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAKGLEPMLEASRNGLPVDITKVPPAPVNKDDFALVQRPGPGLSQEAARRYGELTKLIRQQHEMCLNHSNQFTQLGNITETTKFEKLAEDCKRSMDILKQAFVRGLPTPTARFEQRTFSVIKIFPDLSSNDMLLFIVKGINLPTPPGLSPGDLDVFVRFDFPYPNVEEAQKDKTSVIKNTDSPEFKEQFKLCINRSHRGFRRAIQTKGIKFEVVHKGGLFKTDRVLGTAQLKLDALEIACEVREILEVLDGRRPTGGRLEVMVRIREPLTAQQLETTTERWLVIDPVPAAVPTQVAGPKGKAPPVPAPARESGNRSARPLHSLSVLAFDQERLERKILALRQARRPVPPEVAQQYQDIMQRSQWQRAQLEQGGVGIRREYAAQLERQLQFYTEAARRLGNDGSRDAAKEALYRRNLVESELQRLRR
• Conjugate: MaxLight405
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-CC2D1A antibody

CC2D1A is a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in nonsyndromic mental retardation-3.

Product Categories/Family for anti-CC2D1A antibody

Antibodies; Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 96974985
• NCBI GeneID: 54862
• NCBI Accession #: NP_060191.3
• NCBI GenBank Nucleotide #: NM_017721
• UniProt Accession #: Q6P1N0; Q7Z435; Q86XV0; Q8NF89; Q9H603; Q9NXI1
• Molecular Weight: 103,934 Da
• NCBI Official Full Name: coiled-coil and C2 domain-containing protein 1A
• NCBI Official Synonym Full Names: coiled-coil and C2 domain containing 1A
• NCBI Official Symbol: CC2D1A
• NCBI Official Synonym Symbols: MRT3; FREUD-1; Freud-1/Aki1
• NCBI Protein Information: coiled-coil and C2 domain-containing protein 1A
• UniProt Protein Name: Coiled-coil and C2 domain-containing protein 1A
• Protein Family: Coiled-coil and C2 domain-containing protein
• UniProt Gene Name: CC2D1A
• UniProt Synonym Gene Names: AKI1; FRE under dual repression-binding protein 1; Freud-1
• UniProt Entry Name: C2D1A_HUMAN

NCBI Description

This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in a nonsyndromic form of cognitive disability (MRT3). [provided by RefSeq, Jul 2017]

Uniprot Description

CC2D1A: a transcription factor that binds specifically to the FRE (five repressor element) and represses 5- HT1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of 5- HT1A associated with anxiety and major depression. Mediates HDAC-independent repression of 5- HT1A promoter in neuronal cells. Three alternatively spliced human isoforms have been described.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 19p13.12

Cellular Component: membrane; cytoplasm; microtubule organizing center; nucleus

Molecular Function: signal transducer activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; signal transduction

Disease: Mental Retardation, Autosomal Recessive 3