Western Blot (WB)
(CC2D1A Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CC2D1A antibody detected the CC2D1A protein (arrow).)
Rabbit CC2D1A Polyclonal Antibody | anti-CC2D1A antibody
CC2D1A Antibody (N-term)
Western Blot (WB)
(CC2D1A Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CC2D1A antibody detected the CC2D1A protein (arrow).)
Western Blot (WB)
(CC2D1A Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CC2D1A antibody detected the CC2D1A protein (arrow).)
to a conserved 14-bp 5'-repressor element and regulates expression
of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal
cells. The DNA binding and transcriptional repressor activities of
the protein are inhibited by calcium. A mutation in this gene
results in nonsyndromic mental retardation-3.
Nakamura, A., et al. Biochem. Biophys. Res. Commun. 393(4):872-876(2010)
Nakamura, A., et al. J. Cell Biol. 187(5):607-614(2009)
McKay, G.J., et al. Invest. Ophthalmol. Vis. Sci. 50(2):533-539(2009)
Rogaeva, A., et al. Eur. J. Neurosci. 26(4):965-974(2007)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in nonsyndromic mental retardation-3.[provided by RefSeq, Oct 2009]
Uniprot Description
CC2D1A: a transcription factor that binds specifically to the FRE (five repressor element) and represses 5- HT1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of 5- HT1A associated with anxiety and major depression. Mediates HDAC-independent repression of 5- HT1A promoter in neuronal cells. Three alternatively spliced human isoforms have been described.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 19p13.12
Cellular Component: membrane; cytoplasm; microtubule organizing center; nucleus
Molecular Function: signal transducer activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; signal transduction
Disease: Mental Retardation, Autosomal Recessive 3
Research Articles on CC2D1A
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Product Notes
The CC2D1A cc2d1a (Catalog #AAA9213287) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 143-172. The CC2D1A Antibody (N-term) reacts with Human (Predicted Reactivity: Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's CC2D1A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the CC2D1A cc2d1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CC2D1A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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