Western Blot (WB)
(Western Blot analysis of various cells with Caveolin-1 Polyclonal Antibody.)
Rabbit Caveolin-1 Polyclonal Antibody | anti-CAV1 antibody
Caveolin-1 Polyclonal Antibody
Western Blot (WB)
(Western Blot analysis of various cells with Caveolin-1 Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of various cells with Caveolin-1 Polyclonal Antibody.)
NCBI and Uniprot Product Information
Observed MW: 25
NCBI Description
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]
Uniprot Description
Caveolin-1: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin. Interacts with rotavirus A NSP4. Interacts (via the N- terminus) with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 and JUP. Interacts with BMX and BTK. Expressed in muscle and lung, less so in liver, brain and kidney. Belongs to the caveolin family. 2 isoforms of the human protein are produced by alternative initiation.
Protein type: Adaptor/scaffold; Nuclear receptor co-regulator; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q31.1
Cellular Component: acrosomal membrane; apical plasma membrane; basal plasma membrane; basolateral plasma membrane; caveola; cell cortex; cell surface; cilium; cytoplasmic vesicle; cytosol; early endosome membrane; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; focal adhesion; Golgi membrane; integral to plasma membrane; intracellular; lipid particle; lipid raft; membrane; mitochondrion; perinuclear region of cytoplasm; peroxisomal membrane; plasma membrane; protein complex
Molecular Function: ATPase binding; cholesterol binding; enzyme binding; identical protein binding; nitric-oxide synthase binding; patched binding; protease activator activity; protein binding; protein binding, bridging; protein complex scaffold; protein heterodimerization activity; protein kinase binding; Rac GTPase binding; receptor binding; structural molecule activity; syntaxin binding
Biological Process: angiogenesis; blood coagulation; calcium ion homeostasis; calcium ion transport; cellular calcium ion homeostasis; cellular response to starvation; cholesterol efflux; cholesterol homeostasis; cholesterol transport; cytosolic calcium ion homeostasis; inactivation of MAPK activity; lactation; leukocyte migration; maintenance of cellular protein localization; mammary gland development; mammary gland involution; MAPKKK cascade; membrane depolarization; microtubule polymerization; negative regulation of BMP signaling pathway; negative regulation of cytokine and chemokine mediated signaling pathway; negative regulation of endothelial cell proliferation; negative regulation of epithelial cell differentiation; negative regulation of JAK-STAT cascade; negative regulation of MAPKKK cascade; negative regulation of neuron differentiation; negative regulation of nitric oxide biosynthetic process; negative regulation of nitric-oxide synthase activity; negative regulation of peptidyl-serine phosphorylation; negative regulation of pinocytosis; negative regulation of protein binding; negative regulation of protein ubiquitination; negative regulation of smooth muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of tyrosine phosphorylation of Stat5 protein; nitric oxide homeostasis; nitric oxide metabolic process; organ regeneration; positive regulation of endocytosis; positive regulation of endothelial cell proliferation; positive regulation of metalloenzyme activity; positive regulation of microtubule polymerization; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein binding; positive regulation of protein ubiquitination; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of vasoconstriction; protein homooligomerization; protein localization; receptor internalization; receptor mediated endocytosis of virus by host; regulation of blood coagulation; regulation of fatty acid metabolic process; regulation of nitric-oxide synthase activity; regulation of peptidase activity; regulation of smooth muscle contraction; regulation of the force of heart contraction by chemical signal; response to bacterium; response to calcium ion; response to drug; response to estrogen stimulus; response to gamma radiation; response to glucocorticoid stimulus; response to hypoxia; response to nutrient; response to progesterone stimulus; sequestering of lipid; skeletal muscle development; T cell costimulation; triacylglycerol metabolic process; vascular endothelial growth factor receptor signaling pathway; vasculogenesis; vasoconstriction; vesicle organization and biogenesis
Disease: Lipodystrophy, Congenital Generalized, Type 3; Partial Lipodystrophy, Congenital Cataracts, And Neurodegeneration Syndrome; Pulmonary Hypertension, Primary, 3
Research Articles on CAV1
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Product Notes
The CAV1 cav1 (Catalog #AAA2539474) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Caveolin-1 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Caveolin-1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:500-1:2000, ELISA: 1:5000-1:20000. Researchers should empirically determine the suitability of the CAV1 cav1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Caveolin-1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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