Testing Data
Rabbit anti-Human, Mouse Cathepsin S Polyclonal Antibody | anti-CTSS antibody
Cathepsin S Antibody
30 ug (0.5 mg/ml) of antibody in PBS pH 7.2; 0.01 % BSA; 0.03 % ProClin; and 50 % glycerol.
The antibody solution should be gently mixed before use.
Testing Data
Testing Data
Cathepsin S (CTSS) is a lysosomal cysteine protease of the papain family and may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. CTSS is synthesized as inactive precursor of 331 amino acids consisting of a 15-aa signal peptide; a propeptide of 99 aa; and a mature polypeptide of 217 aa. It is activated in the lysosomes by a proteolytic cleavage of the propeptide. The deduced amino acid sequence contains only one potential N-glycosylation site located in the propeptide. Compared with the abundant cathepsins B; L and H; cathepsin S shows a restricted tissue distribution; with highest levels in spleen; heart; and lung. In addition; evidences indicate that cathepsin S generates amyloid beta-peptide from amyloidogenic fragments of amyloid precursor protein (APP) in the endosomal/lysosomal compartment; and is implicated in the pathogenesis of Alzheimer's disease and Down Syndrome.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Uniprot Description
CTSS: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. Belongs to the peptidase C1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.22.27; Protease
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component: extracellular region; extracellular space; intracellular membrane-bound organelle; lysosomal lumen; lysosome
Molecular Function: collagen binding; cysteine-type endopeptidase activity; fibronectin binding; laminin binding; proteoglycan binding; serine-type endopeptidase activity
Biological Process: adaptive immune response; antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen; collagen catabolic process; extracellular matrix disassembly; immune response; neutrophil degranulation; protein processing; proteolysis; proteolysis involved in cellular protein catabolic process; response to acidity; toll-like receptor signaling pathway
Research Articles on CTSS
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Product Notes
The CTSS ctss (Catalog #AAA845519) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cathepsin S Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Cathepsin S can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1-4 ug. Researchers should empirically determine the suitability of the CTSS ctss for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cathepsin S, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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