Rabbit Catenin-delta1 Polyclonal Antibody | anti-G224 antibody

Catenin-delta1 (G224) Polyclonal Antibody

Cat. Num. AAA3003282

• Gene Names: CTNND1; CAS; p120; BCDS2; CTNND; P120CAS; P120CTN; p120(CAS); p120(CTN)
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: Catenin-delta1; Polyclonal Antibody; Catenin-delta1 (G224) Polyclonal Antibody; Catenin delta1; Catenin delta-1; Cadherin-associated Src substrate; Short name=CAS; p120 catenin; p120(ctn); p120(cas); CTNND1; KIAA0384; anti-G224 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Catenin-delta1 (G224) polyclonal antibody detects endogenous levels of Catenin-delta1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 968

• Applicable Applications for anti-G224 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 201-250 of Human Catenin-delta1.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of Catenin-delta1 (G224) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50.)

Related Product Information for anti-G224 antibody

The alpha, beta, delta, and gamma -catenins are proteins that bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. delta-catenin interacts with Presenilin 1 and is expressed in the brain. The gene encoding delta-catenin maps to human chromosome 5p15.2. A hemizygous loss of the gene encoding delta-catenin leads to the mental retardation associated with Cri-du-Chat syndrome. gamma-catenin, also known as plakoglobin, is an 80-88 kDa protein that binds alpha-catenin and N-cadherin. In addition, the transmembrane phosphatase PTPm associates with catenin/cadherin complexes and may regulate complex signaling.

NCBI and Uniprot Product Information

• NCBI GI #: 146231940
• NCBI GeneID: 1500
• NCBI Accession #: NP_001078927.1
• NCBI GenBank Nucleotide #: NP_001078927.1
• UniProt Accession #: O60716
• Molecular Weight: ~ 108kDa
• NCBI Official Full Name: catenin delta-1 isoform 1ABC
• NCBI Official Synonym Full Names: catenin delta 1
• NCBI Official Symbol: CTNND1
• NCBI Official Synonym Symbols: CAS; p120; BCDS2; CTNND; P120CAS; P120CTN; p120(CAS); p120(CTN)
• NCBI Protein Information: catenin delta-1
• UniProt Protein Name: Catenin delta-1
• UniProt Gene Name: CTNND1
• UniProt Synonym Gene Names: KIAA0384; CAS; p120(ctn)
• UniProt Entry Name: CTND1_HUMAN

NCBI Description

This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010]

Uniprot Description

CTNND1: an Arm repeat protein that interacts with varied components such as cadherin, small G proteins, kinases, and the Kaiso transcriptional repressor. A downstream modulator of Wnt/beta-catenin signaling pathway whose stability may be regulated downstream of Dsh. Required for the invasiveness of E-cadherin-deficient cells. A signal coordinator between cadherins and Rho-family GTPases to regulate cytoskeletal changes required during dendritic spine and synapse development. The association of catenins with cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Thirty two splice-variant isoforms have been described.

Protein type: Adaptor/scaffold; G protein regulator, misc.; Motility/polarity/chemotaxis; Cell adhesion; Actin-binding

Chromosomal Location of Human Ortholog: 11q11

Cellular Component: growth cone; lamellipodium; cytoplasm; dendritic spine; plasma membrane; synapse; intercellular junction; midbody; zonula adherens; nucleus; cytosol

Molecular Function: protein binding; cadherin binding; protein kinase binding; receptor binding

Biological Process: intercellular junction assembly and maintenance; cell-cell adhesion; Wnt receptor signaling pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent; brain development; vascular endothelial growth factor receptor signaling pathway; cell adhesion