Rabbit anti-Human Caspase recruitment domain-containing protein 8 Polyclonal Antibody | anti-CARD8 antibody

Rabbit anti-human Caspase recruitment domain-containing protein 8 polyclonal Antibody(CARD8)

Cat. Num. AAA1492084

• Gene Names: CARD8; NDPP; DACAR; DAKAR; NDPP1; TUCAN; CARDINAL
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen Affinity Purified
• Synonyms: Caspase recruitment domain-containing protein 8; Polyclonal Antibody; Rabbit anti-human Caspase recruitment domain-containing protein 8 polyclonal Antibody(CARD8); Apoptotic protein NDPP1; CARD-inhibitor of NF-kappa-B-activating ligand; CARDINAL; DACAR; Tumor up-regulated CARD-containing antagonist of CASP9; TUCAN; CARD8; KIAA0955; NDPP1; anti-CARD8 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Sequence Length: 537

• Applicable Applications for anti-CARD8 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: Recommended dilution: IHC:1:20-1:200
• Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Conjugate: Non-conjugated
• Immunogen: Recombinant human Caspase recruitment domain-containing protein 8 protein(1-200aa)
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-68154 / sc-68156
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human tonsil using MBS1492084 at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human rectal cancer using MBS1492084 at dilution 1:100)

Related Product Information for anti-CARD8 antibody

Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.

NCBI and Uniprot Product Information

• NCBI GI #: 296531357
• NCBI GeneID: 22900
• NCBI Accession #: NP_001171829.1
• NCBI GenBank Nucleotide #: NM_001184900.1
• UniProt Accession #: Q9Y2G2; Q6PGP8; Q96P82; B5KVR6; B7Z496; B7Z4A2; E9PEM7; G3XAM9
• Molecular Weight: 60,652 Da
• NCBI Official Full Name: caspase recruitment domain-containing protein 8 isoform a
• NCBI Official Synonym Full Names: caspase recruitment domain family member 8
• NCBI Official Symbol: CARD8
• NCBI Official Synonym Symbols: NDPP; DACAR; DAKAR; NDPP1; TUCAN; CARDINAL
• NCBI Protein Information: caspase recruitment domain-containing protein 8
• UniProt Protein Name: Caspase recruitment domain-containing protein 8
• Protein Family: Caspase recruitment domain-containing protein
• UniProt Gene Name: CARD8
• UniProt Synonym Gene Names: KIAA0955; NDPP1; CARDINAL; TUCAN
• UniProt Entry Name: CARD8_HUMAN

NCBI Description

The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

Uniprot Description

CARD8: Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Inhibitor

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: caspase activator activity; NACHT domain binding; protein binding; protein homodimerization activity

Biological Process: caspase activation; negative regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of caspase activity; positive regulation of interleukin-1 beta secretion