Testing Data
Rabbit Caspase 13, aa91-105 Polyclonal Antibody | anti-CASP4 antibody
Caspase 13, aa91-105 (ERICE)
Gene Names
CASP4; CASP13
Reactivity
Human, Mouse, Rat
Applications
Western Blot
Purity
Highly PurifiedSupplied as chromatographically purified IgG
Synonyms
Caspase 13; aa91-105; Polyclonal Antibody; aa91-105 (ERICE); Anti -Caspase 13; anti-CASP4 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human, mouse and rat Caspase-13/ERICE
Purity/Purification
Highly Purified
Supplied as chromatographically purified IgG
Supplied as chromatographically purified IgG
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Applicable Applications for anti-CASP4 antibody
Western Blot (WB)
Immunogen
Peptide corresponding to amino acids 91 to 105 of human Acaspase-13
Preparation and Storage
-20 degree C
Testing Data
Testing Data
Testing Data
Testing Data
Testing Data
Testing Data
Related Product Information for anti-CASP4 antibody
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 b Converting Enzyme) and caspase-13 (1). Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines (1).
This polyclonal antibody can be used for detection of AIF by Western blot at 0.5 to 1ug/ml. HL60 cell lysate can be used as positive control and a 43kD band should be detected. It is human, mouse and rat reactive.
This polyclonal antibody can be used for detection of AIF by Western blot at 0.5 to 1ug/ml. HL60 cell lysate can be used as positive control and a 43kD band should be detected. It is human, mouse and rat reactive.
Product Categories/Family for anti-CASP4 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
43,012 Da
NCBI Official Full Name
caspase-4
NCBI Official Synonym Full Names
caspase 4, apoptosis-related cysteine peptidase
NCBI Official Symbol
CASP4
NCBI Official Synonym Symbols
CASP13
NCBI Protein Information
caspase-4; ERICE; CASP-4; CASP-13; caspase 13; caspase-13; caspase 4, apoptosis-related cysteine protease; evolutionary related interleukin-1-beta-converting enzyme
UniProt Protein Name
Caspase-13
Protein Family
UniProt Gene Name
CASP13
UniProt Synonym Gene Names
CASP-13; ERICE
UniProt Entry Name
CASPD_BOVIN
Uniprot Description
CASP4: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit. Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain. Belongs to the peptidase C14A family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Protease; EC 3.4.22.64
Cellular Component: endoplasmic reticulum membrane; mitochondrion; cytoplasm
Molecular Function: cysteine-type endopeptidase activity
Biological Process: regulation of apoptosis; apoptosis; germ cell programmed cell death; regulation of inflammatory response; positive regulation of interleukin-1 beta secretion; proteolysis
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Product Notes
The CASP4 casp13 (Catalog #AAA643192) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Caspase 13, aa91-105 (ERICE) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Caspase 13, aa91-105 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the CASP4 casp13 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Caspase 13, aa91-105, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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