Immunohistochemistry (IHC)
(Immunohistochemistry (IHC) analyzes of CARD6 (A2) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.)
Rabbit anti-Human CARD6 Polyclonal Antibody | anti-CARD6 antibody
CARD6 (A2) Polyclonal Antibody
Gene Names
CARD6; CINCIN1
Reactivity
Human
Applications
Immunohistochemistry, Immunofluorescence
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
CARD6; Polyclonal Antibody; CARD6 (A2) Polyclonal Antibody; Caspase recruitment domain-containing protein 6; CARD-6; anti-CARD6 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
CARD6/CINCIN1 (A2) polyclonal antibody detects endogenous levels of CARD6/CIN protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
1037
Applicable Applications for anti-CARD6 antibody
Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
IHC: 1:50-1:200
IF: 1:50-1:200
IF: 1:50-1:200
Immunogen
Synthetic peptide, corresponding to the N-terminual of Human CARD6.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunohistochemistry (IHC) analyzes of CARD6 (A2) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.)
Immunohistochemistry (IHC)
(Immunohistochemistry (IHC) analyzes of CARD6 (A2) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.)
Related Product Information for anti-CARD6 antibody
Membrane-associated guanylate kinase (MAGUK) family members localize to the plasma membrane and function as molecular scaffolds for the assembly of multi-protein complexes. The MAGUK family includes several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product, such as postsynaptic proteins, GKAPs, the tight junction associated proteins (ZO-1-3) and the caspase-associated recruitment domain (CARD) proteins, CARD 6, CARD 8-12 and CARD 14. CARD 6 is a 311 amino acid protein that associates with microtubules and acts as a selective mediator of NFkappaB activation. CARD 6 is structurally and functionally related to the superfamily of interferon (IFN)-inducible GTPases, a group that comprises host defense proteins which mediate cell-autonomous immunity. RICK, the receptorinteracting protein (RIP)-like interacting caspase-like apoptosis regulatory protein kinase, interacts with CARD 6 and targets it to aggresomes, regions of the cell where protein aggregates collect.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~ 116kDa
NCBI Official Full Name
caspase recruitment domain-containing protein 6
NCBI Official Synonym Full Names
caspase recruitment domain family member 6
NCBI Official Symbol
CARD6
NCBI Official Synonym Symbols
CINCIN1
NCBI Protein Information
caspase recruitment domain-containing protein 6
UniProt Protein Name
Caspase recruitment domain-containing protein 6
Protein Family
UniProt Gene Name
CARD6
UniProt Entry Name
CARD6_HUMAN
NCBI Description
This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB. [provided by RefSeq, Jul 2008]
Uniprot Description
CARD6: May be involved in apoptosis.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 5p13.1
Biological Process: regulation of apoptosis; apoptosis
Research Articles on CARD6
Similar Products
Product Notes
The CARD6 card6 (Catalog #AAA3000360) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CARD6 (A2) Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CARD6 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Immunofluorescence (IF). IHC: 1:50-1:200 IF: 1:50-1:200. Researchers should empirically determine the suitability of the CARD6 card6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CARD6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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