Rabbit anti-Human, Mouse Carabin Polyclonal Antibody | anti-TBC1D10C antibody
Carabin (FLJ00332, MGC46488, TBC1 Domain Family Member 10C, TBC1D10C)
Gene Names
TBC1D10C; CARABIN; FLJ00332; MGC46488
Reactivity
Human, Mouse
Applications
Western Blot
Purity
Affinity PurifiedPurified by affinity chromatography.
Synonyms
Carabin; Polyclonal Antibody; Carabin (FLJ00332; MGC46488; TBC1 Domain Family Member 10C; TBC1D10C); Anti -Carabin (FLJ00332; anti-TBC1D10C antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human Carabin at ~55kD. Does not crossreact with either TBC1D10A or TBC1D10B. Species Crossreactivity: mouse
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Purified by affinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Applicable Applications for anti-TBC1D10C antibody
Western Blot (WB)
Application Notes
Suitable for use in Western Blot.
Dilution: Western Blot: 1-2ug/ml
Dilution: Western Blot: 1-2ug/ml
Immunogen
Synthetic peptide corresponding to a 17aa from near the amino terminus of human Carabin.
Positive Control
Human spleen cell lysates
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Related Product Information for anti-TBC1D10C antibody
Carabin is a 50kD protein belonging to the TBC1 domain family of proteins. Carabin differs from other members of the TBC1 domain protein family, which appear to play a role in the regulation of cell growth and differentiation. Studies demonstrate that Carabin is part of a negative regulatory loop for the intracellular TCR signalling pathway and acts as an inhibitor of the Ras signalling pathway. Carabin is also believed to mediate crosstalk between calcineurin and Ras. Carabin is most abundantly expressed in spleen and peripheral blood leucocytes.
Product Categories/Family for anti-TBC1D10C antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
49,712 Da
NCBI Official Full Name
carabin
NCBI Official Synonym Full Names
TBC1 domain family, member 10C
NCBI Official Symbol
TBC1D10C
NCBI Official Synonym Symbols
CARABIN; FLJ00332; MGC46488
NCBI Protein Information
carabin; OTTHUMP00000235294; OTTHUMP00000235295; OTTHUMP00000236402
UniProt Protein Name
Carabin
Protein Family
UniProt Gene Name
TBC1D10C
UniProt Entry Name
TB10C_HUMAN
NCBI Description
Carabin is an endogenous inhibitor of calcineurin (see MIM 114105) that also inhibits the Ras (see MIM 190020) signaling pathway through its intrinsic Ras GTPase-activating protein activity (Pan et al., 2007 [PubMed 17230191]).[supplied by OMIM]
Uniprot Description
TBC1D10C: Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.
Protein type: GAPs, Rab; GAPs
Chromosomal Location of Human Ortholog: 11q13.2
Cellular Component: filopodium membrane; membrane; plasma membrane
Biological Process: negative regulation of B cell activation; negative regulation of NFAT protein import into nucleus; retrograde transport, endosome to Golgi
Research Articles on TBC1D10C
Similar Products
Product Notes
The TBC1D10C tbc1d10c (Catalog #AAA619296) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Carabin (FLJ00332, MGC46488, TBC1 Domain Family Member 10C, TBC1D10C) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Carabin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Dilution: Western Blot: 1-2ug/ml. Researchers should empirically determine the suitability of the TBC1D10C tbc1d10c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Carabin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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