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Western Blot (WB) (Western blot analysis of CAPS2 in human brain tissue lysate with CAPS2 antibody at (A) 0.5 and (B) 1 μg/mL.)

Rabbit CAPS2 Polyclonal Antibody | anti-CADPS2 antibody

CAPS2 Antibody

Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
Purity
CAPS2 Antibody is affinity chromatography purified via peptide column.
Synonyms
CAPS2; Polyclonal Antibody; CAPS2 Antibody; KIAA1591; Calcium-dependent secretion activator 2; Calcium-dependent activator protein for secretion 2; CAPS-2; Ca++-dependent secretion activator 2; anti-CADPS2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
This CAPS2 antibody is predicted to be specific to CAPS2 and not recognize CAPS1.
Purity/Purification
CAPS2 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid; CAPS2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration
1 mg/mL (varies by lot)
Sequence Length
1296
Applicable Applications for anti-CADPS2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry-paraffin (IHC-p), Immunofluorescence (IF)
Application Notes
Optimal dilutions for each application to be determined by the researcher.
The information provided is a guidline for product use. This product is for research use only.
Conjugate
Unconjugated
Immunogen
CAPS2 antibody was raised against a 19 amino acid synthetic peptide near the center of the human CAPS2. The immunogen is located within amino acids 510-560 of CAPS2.
Preparation and Storage
CAPS2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of CAPS2 in human brain tissue lysate with CAPS2 antibody at (A) 0.5 and (B) 1 μg/mL.)

Western Blot (WB) (Western blot analysis of CAPS2 in human brain tissue lysate with CAPS2 antibody at (A) 0.5 and (B) 1 μg/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of CAPS2 in human brain with CAPS2 antibody at 5 μg/mL.)

Immunohistochemistry (IHC) (Immunohistochemistry of CAPS2 in human brain with CAPS2 antibody at 5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of CAPS2 in Human Brain tissue with CAPS2 antibody at 20 μg/mL.)

Immunofluorescence (IF) (Immunofluorescence of CAPS2 in Human Brain tissue with CAPS2 antibody at 20 μg/mL.)
Related Product Information for anti-CADPS2 antibody
CAPS2 Antibody: CAPS2 and the related protein CAPS1 encode novel neural/endocrine-specific cytosolic and peripheral membrane proteins. Both are essential components of the synaptic vesicle priming machinery and are required for the Ca2+-regulated exocytosis of secretory vesicles; CAPS-deficient neurons contain no or very few fusion competent synaptic vesicles, causing a selective impairment of fast phasic transmitter release. Like CAPS1, numerous isoforms of CAPS2 are known to exist. These isoforms show distinct expression patterns in the brain. For example, CAPS2b showed high expression in the developing cerebellum. Furthermore, one version of CAPS2 mRNA that lacks exon 3 is detected in some autistic patients, suggesting that the differential expression pattern of CAPS2 is involved in neuronal development.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
142,883 Da
NCBI Official Full Name
calcium-dependent secretion activator 2 isoform a
NCBI Official Synonym Full Names
Ca++-dependent secretion activator 2
NCBI Official Symbol
CADPS2
NCBI Protein Information
calcium-dependent secretion activator 2; CAPS-2; Ca2+-dependent activator protein for secretion 2; calcium-dependent activator protein for secretion 2
UniProt Protein Name
Calcium-dependent secretion activator 2
UniProt Gene Name
CADPS2
UniProt Synonym Gene Names
CAPS2; KIAA1591; CAPS-2
UniProt Entry Name
CAPS2_HUMAN

NCBI Description

This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

Uniprot Description

CADPS2: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)- dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 7q31.3

Cellular Component: presynaptic membrane; postsynaptic membrane; cytoplasmic vesicle membrane; cell junction

Molecular Function: metal ion binding; lipid binding

Biological Process: protein transport; cellular response to starvation; synaptic vesicle priming; positive regulation of exocytosis

Research Articles on CADPS2

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Product Notes

The CADPS2 cadps2 (Catalog #AAA150554) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CAPS2 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CAPS2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry-paraffin (IHC-p), Immunofluorescence (IF). Optimal dilutions for each application to be determined by the researcher. The information provided is a guidline for product use. This product is for research use only. Researchers should empirically determine the suitability of the CADPS2 cadps2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CAPS2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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