Western Blot (WB)
((0.1ug/ml) staining of Rat Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Goat Cannabinoid Receptor 1 Polyclonal Antibody | anti-CNR1 antibody
Goat anti-Cannabinoid Receptor 1 Antibody
Western Blot: Approx 65kDa band observed in Rat Brain lysates (calculated MW of 52.7kDa according to Rat NP_036916.1 and 52.9kDa according to Human NP_057167.2). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Porcella et al, Eur J Neurosci.2000 Mar;12(3): 1123-7. PMID: 10762343). Recommended concentration: 0.1-0.3ug/ml.
Western Blot (WB)
((0.1ug/ml) staining of Rat Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Western Blot (WB)
((0.1ug/ml) staining of Rat Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]
Uniprot Description
CNR1: Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR
Chromosomal Location of Human Ortholog: 6q14-q15
Cellular Component: axon; growth cone; integral to plasma membrane; intracellular membrane-bound organelle; lipid raft; plasma membrane
Molecular Function: cannabinoid receptor activity; drug binding
Biological Process: aging; axonal fasciculation; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to cyclic nucleotide second messenger; glucose homeostasis; maternal process involved in pregnancy; memory; negative regulation of action potential; negative regulation of blood pressure; negative regulation of dopamine secretion; negative regulation of fatty acid beta-oxidation; negative regulation of mast cell activation; negative regulation of nitric-oxide synthase activity; positive regulation of acute inflammatory response to antigenic stimulus; positive regulation of apoptosis; positive regulation of blood pressure; positive regulation of fever; regulation of insulin secretion; regulation of synaptic transmission, GABAergic; regulation of synaptic transmission, glutamatergic; response to cocaine; response to ethanol; response to lipopolysaccharide; response to morphine; response to nicotine; response to nutrient; sensory perception of pain; spermatogenesis
Research Articles on CNR1
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Product Notes
The CNR1 cnr1 (Catalog #AAA420085) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-Cannabinoid Receptor 1 Antibody reacts with Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog and may cross-react with other species as described in the data sheet. AAA Biotech's Cannabinoid Receptor 1 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot (WB). Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Approx 65kDa band observed in Rat Brain lysates (calculated MW of 52.7kDa according to Rat NP_036916.1 and 52.9kDa according to Human NP_057167.2). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Porcella et al, Eur J Neurosci.2000 Mar;12(3): 1123-7. PMID: 10762343). Recommended concentration: 0.1-0.3ug/ml. Researchers should empirically determine the suitability of the CNR1 cnr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: HTSEDGKVQV TRPDQ. It is sometimes possible for the material contained within the vial of "Cannabinoid Receptor 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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