Rabbit anti-Mouse Camk2a Polyclonal Antibody | anti-Camk2a antibody

Camk2a, CT (Camk2a, Calcium/calmodulin-dependent protein kinase type II subunit alpha) (Biotin)

Cat. Num. AAA6280597

• Gene Names: Camk2a; CaMKII; R74975; mKIAA0968
• Reactivity: Mouse
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: Camk2a; Polyclonal Antibody; CT (Camk2a; Calcium/calmodulin-dependent protein kinase type II subunit alpha) (Biotin); Calcium/calmodulin-dependent protein kinase type II subunit alpha; anti-Camk2a antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes mouse Camk2a.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-Camk2a antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 322-349 in the C-terminal region of mouse Camk2a, UniProt Accession #P11798. Species sequence homology: human, rat
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis using MBS6011836 in mouse brain tissue lysates (35ug/lane). This demonstrates the Camk2a antibody detected the Camk2a protein (arrow).)

Related Product Information for anti-Camk2a antibody

CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).

Product Categories/Family for anti-Camk2a antibody

Antibodies; Protein Kinases

References

1. Hund, T.J., et al. J. Clin. Invest. 120(10):3508-3519 (2010). 2. Xu, L., et al. Circ. Res. 107(3):398-407 (2010). 3. Guetg, N., et al. Proc. Natl. Acad. Sci. U.S.A. 107(31):13924-13929 (2010). 4. Blaich, A., et al. Proc. Natl. Acad. Sci. U.S.A. 107(22):10285-10289 (2010). 5. Jenkins, M.A., et al. J. Neurosci. 30(15):5125-5135 (2010).

NCBI and Uniprot Product Information

• NCBI GI #: 28916677
• NCBI GeneID: 12322
• NCBI Accession #: NP_803126.1; NP_033922.1
• NCBI GenBank Nucleotide #: NM_177407.4
• UniProt Accession #: P11798; Q61284; Q6ZWN4
• Molecular Weight: 22,584 Da
• NCBI Official Full Name: calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2
• NCBI Official Synonym Full Names: calcium/calmodulin-dependent protein kinase II alpha
• NCBI Official Symbol: Camk2a
• NCBI Official Synonym Symbols: CaMKII; R74975; mKIAA0968
• NCBI Protein Information: calcium/calmodulin-dependent protein kinase type II subunit alpha
• UniProt Protein Name: Calcium/calmodulin-dependent protein kinase type II subunit alpha
• Protein Family: Calcium/calmodulin-dependent protein kinase
• UniProt Gene Name: Camk2a
• UniProt Synonym Gene Names: CaM kinase II subunit alpha; CaMK-II subunit alpha
• UniProt Entry Name: KCC2A_MOUSE

Uniprot Description

CAMK2A: a protein kinase of the CAMK2 family. A prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses that may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. The holoenzyme is composed of four different chains: alpha, beta, gamma, and delta. The different chains assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. May interact with BAALC, MPDZ, SYN1 and synGAP. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.11.17; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CAMK group; CAMK2 family

Cellular Component: dendrite cytoplasm; mitochondrion; cell soma; membrane; axon; cytoplasm; dendrite; postsynaptic density; plasma membrane; synapse; cell junction; nucleus

Molecular Function: glutamate receptor binding; protein homodimerization activity; calmodulin-dependent protein kinase activity; nucleotide binding; GTPase activating protein binding; protein kinase activity; calmodulin binding; transferase activity; protein serine/threonine kinase activity; protein binding; transferase activity, transferring phosphorus-containing groups; kinase activity; ATP binding

Biological Process: peptidyl-serine phosphorylation; ionotropic glutamate receptor signaling pathway; protein amino acid autophosphorylation; calcium ion transport; regulation of neurotransmitter secretion; positive regulation of calcium ion transport; protein amino acid phosphorylation; phosphorylation; G1/S transition of mitotic cell cycle; activation of NF-kappaB transcription factor; regulation of neuronal synaptic plasticity