Rabbit CALY Polyclonal Antibody | anti-CALY antibody

CALY Polyclonal Antibody

Cat. Num. AAA3006358

• Gene Names: CALY; NSG3; DRD1IP
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: CALY; Polyclonal Antibody; CALY Polyclonal Antibody; Neuron-specific vesicular protein calcyon; DRD1IP; anti-CALY antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: CALY polyclonal antibody detects endogenous levels of CALY protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 217

• Applicable Applications for anti-CALY antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human CALY.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of CALY polyclonal antibody at 1:500 dilutionLane1:A549 whole cell lysateLane2:Raw264. 7 whole cell lysateLane3:H9C2 whole cell lysate)

Related Product Information for anti-CALY antibody

Calcyon is a single transmembrane protein that interacts with D1 dopamine receptors. Dopamine is a neurotransmitter that regulates synaptic transmission involved in learning and memory. D1 receptors, the most abundant dopamine receptor in the central nervous system, appear to modulate the activity of D2 dopamine receptors, mediate various behavioural responses, and regulate neuron growth and differentiation. Calcyon is present in neuronal cell bodies and processes of the cortex and hippocampus, and it is especially abundant in pyramidal neurons. Interaction of Calcyon with D1 receptors results in a release of intracellular calcium.

NCBI and Uniprot Product Information

• NCBI GI #: 7656955
• NCBI GeneID: 50632
• NCBI Accession #: NP_056537.1
• NCBI GenBank Nucleotide #: NP_056537.1
• UniProt Accession #: Q9NYX4
• Molecular Weight: ~ 23kDa
• NCBI Official Full Name: neuron-specific vesicular protein calcyon isoform 1
• NCBI Official Synonym Full Names: calcyon neuron specific vesicular protein
• NCBI Official Symbol: CALY
• NCBI Official Synonym Symbols: NSG3; DRD1IP
• NCBI Protein Information: neuron-specific vesicular protein calcyon
• UniProt Protein Name: Neuron-specific vesicular protein calcyon
• Protein Family: Neuron-specific vesicular protein calcyon
• UniProt Gene Name: CALY
• UniProt Synonym Gene Names: DRD1IP
• UniProt Entry Name: CALY_HUMAN

NCBI Description

The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with D1 dopamine receptor and may interact with other DA receptor subtypes and/or GPCRs. [provided by RefSeq, Jul 2008]

Uniprot Description

calcyon: Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis. Belongs to the NSG family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 10q26.3

Cellular Component: cytoplasmic vesicle membrane; integral to plasma membrane; cytoplasmic vesicle

Molecular Function: protein complex binding; clathrin light chain binding

Biological Process: clathrin cage assembly; dopamine receptor signaling pathway; positive regulation of endocytosis; endocytosis