Rabbit Calcitonin Receptor Polyclonal Antibody | anti-CALCR antibody
Calcitonin Receptor
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: Immunohistochemistry (Paraffin): 1:10-1:100. The use of 4% paraformaldehyde fixation, rather than formalin fixation, is recommended. A sensitive detection system is also recommended; e.g. a catalyzed signal amplification system. Paraffin sections do not require protein digestion pre-treatment. Does not require antigen retrieval using heat treatment prior to staining.
ELISA: 1:10,000
Western Blot: Reducing conditions
Optimal working dilutions to be determined by researcher.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq]
Uniprot Description
CALCR: This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. Belongs to the G-protein coupled receptor 2 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, GPCR; GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 7q21.3
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: protein binding; calcitonin binding; receptor activity; protein transporter activity; calcitonin receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; protein transport; elevation of cytosolic calcium ion concentration; phospholipase C activation; receptor internalization; positive regulation of cAMP biosynthetic process; response to glucocorticoid stimulus; adenylate cyclase activation; positive regulation of adenylate cyclase activity; G-protein signaling, adenylate cyclase activating pathway
Disease: Osteoporosis
Research Articles on CALCR
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Product Notes
The CALCR calcr (Catalog #AAA621183) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Calcitonin Receptor reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Calcitonin Receptor can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in Immunohistochemistry, ELISA and Western Blot. Dilution: Immunohistochemistry (Paraffin): 1:10-1:100. The use of 4% paraformaldehyde fixation, rather than formalin fixation, is recommended. A sensitive detection system is also recommended; e.g. a catalyzed signal amplification system. Paraffin sections do not require protein digestion pre-treatment. Does not require antigen retrieval using heat treatment prior to staining. ELISA: 1:10,000 Western Blot: Reducing conditions Optimal working dilutions to be determined by researcher. Researchers should empirically determine the suitability of the CALCR calcr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Calcitonin Receptor, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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