Western Blot (WB)
(Western blot analysis of Cacna2d1 using Jurkat whole cell lysates)
Rabbit Cacna2d1 Polyclonal Antibody | anti-Cacna2d1 antibody
Cacna2d1 Antibody
Gene Names
CACNA2D1; CACNA2; CCHL2A; CACNL2A; LINC01112; lncRNA-N3
Reactivity
Human, Mouse, Rat
Applications
Western Blot, ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Synonyms
Cacna2d1; Polyclonal Antibody; Cacna2d1 Antibody; CA2D1_HUMAN; CACN A2; CACNA2; CACNL2A; Calcium channel L type alpha 2 polypeptide; Calcium channel voltage dependent alpha 2/delta subunit 1; CCHL2A; Dihydropyridine receptor alpha 2 subunit; Dihydropyridine sensitive L type calcium channel alpha 2/delta subunit; Dihydropyridine sensitive L type calcium channel subunits alpha 2/delta; L type calcium channel subunit alpha 2; MHS 3; MHS3; Voltage dependent calcium channel subunit alpha 2/delta 1; Voltage gated calcium channel subunit alpha 2/delta 1; Voltage-dependent calcium channel subunit delta-1; Voltage-gated calcium channel subunit alpha-2/delta-1; anti-Cacna2d1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
Cacna2d1 antibody detects endogenous levels of total Cacna2d1
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Sequence Length
1091
Applicable Applications for anti-Cacna2d1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB: 1:1000-3000
Immunogen
A synthesized peptide derived from human Cacna2d1
Subcellular Location
Membrane.
Tissue Specificity
Isoform 1 is expressed in skeletal muscle. Isoform 2 is expressed in the central nervous system. Isoform 2, isoform 4 and isoform 5 are expressed in neuroblastoma cells. Isoform 3, isoform 4 and isoform 5 are expressed in the aorta.
Predicted Cross Reactivity
Pig, Horse, Rabbit, Dog, Chicken, Xenopus
Similarity
Pig (100%), Horse (92%), Rabbit (100%), Dog (86%), Chicken (83%), Xenopus (82%)
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Western Blot (WB)
(Western blot analysis of Cacna2d1 using Jurkat whole cell lysates)
Western Blot (WB)
(Western blot analysis of Cacna2d1 using Jurkat whole cell lysates)
Related Product Information for anti-Cacna2d1 antibody
Function: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity).
Subunit Structure: Dimer formed of alpha-2-1 and delta-1 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (By similarity).
Post-translational Modifications: Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked.
Similarity: The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch. Belongs to the calcium channel subunit alpha-2/delta family.
Subunit Structure: Dimer formed of alpha-2-1 and delta-1 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (By similarity).
Post-translational Modifications: Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked.
Similarity: The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch. Belongs to the calcium channel subunit alpha-2/delta family.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Observed: 123 kDa
Predicted: 125 kDa
Predicted: 125 kDa
NCBI Official Full Name
voltage-dependent calcium channel subunit alpha-2/delta-1 preproprotein
NCBI Official Synonym Full Names
calcium voltage-gated channel auxiliary subunit alpha2delta 1
NCBI Official Symbol
CACNA2D1
NCBI Official Synonym Symbols
CACNA2; CCHL2A; CACNL2A; LINC01112; lncRNA-N3
NCBI Protein Information
voltage-dependent calcium channel subunit alpha-2/delta-1
UniProt Protein Name
Voltage-dependent calcium channel subunit alpha-2/delta-1
Protein Family
UniProt Gene Name
CACNA2D1
UniProt Synonym Gene Names
CACNL2A; CCHL2A; MHS3
NCBI Description
The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014]
Uniprot Description
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling ().
Research Articles on Cacna2d1
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Product Notes
The Cacna2d1 cacna2d1 (Catalog #AAA9608829) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cacna2d1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Cacna2d1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:1000-3000. Researchers should empirically determine the suitability of the Cacna2d1 cacna2d1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cacna2d1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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