Rabbit CaBP8 Polyclonal Antibody | anti-CALN1 antibody

CaBP8 Antibody

Cat. Num. AAA151204

• Gene Names: CALN1; CABP8
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: CaBP8 Antibody is affinity chromatography purified via peptide column.
• Synonyms: CaBP8; Polyclonal Antibody; CaBP8 Antibody; CABP8; Calcium-binding protein 8; Calneuron I; calneuron 1; anti-CALN1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: CaBP8 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 261

• Applicable Applications for anti-CALN1 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: CaBP8 antibody can be used for detection of CaBP8 by Western blot at 1 - 2 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: CaBP8 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CaBP8.
• Buffer: CaBP8 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: CaBP8 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of CaBP8 in 3T3 cell lysate with CaBP8 antibody at (A) 1 and (B) 2 μg/mL.)

Related Product Information for anti-CALN1 antibody

CaBP8 Antibody: Calcium binding proteins (CaBP) play a crucial role in the calcium-mediated cellular signal transduction pathway in the central nervous system. The CaBP family shares much similarity with CaM I (calmodulin), and it has been shown that CaBP proteins can substitute functionally for, and possibly augment the function of, CaM I. CaBP8, contains two EF-hand domains for calcium binding and shares 70% homology with CaBP7 and 50% homology with CaM I. It negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. Both CaBP8 and CaBP7 possess a targeting mechanism that is unique amongst the CaBPs that may contribute to differential functional Ca2+-sensing by these family members.

NCBI and Uniprot Product Information

• NCBI GI #: 157743275
• NCBI GeneID: 83698
• NCBI Accession #: NP_113656
• NCBI GenBank Nucleotide #: NM_031468.3
• UniProt Accession #: Q9BXU9; J3KQA7
• Molecular Weight: 29,324 Da
• NCBI Official Full Name: calcium-binding protein 8 isoform 1
• NCBI Official Synonym Full Names: calneuron 1
• NCBI Official Symbol: CALN1
• NCBI Official Synonym Symbols: CABP8
• NCBI Protein Information: calcium-binding protein 8; calneuron I; calneuron-1; calcium-binding protein CABP8
• UniProt Protein Name: Calcium-binding protein 8
• Protein Family: Calcium-binding protein
• UniProt Gene Name: CALN1
• UniProt Synonym Gene Names: CABP8; CaBP8
• UniProt Entry Name: CABP8_HUMAN

NCBI Description

This gene encodes a protein with high similarity to the calcium-binding proteins of the calmodulin family. The encoded protein contains two EF-hand domains and potential calcium-binding sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Description

CALN1: Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. May play a role in the physiology of neurons and is potentially important in memory and learning.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q11

Cellular Component: perinuclear region of cytoplasm; plasma membrane; integral to membrane; trans-Golgi network membrane

Molecular Function: calcium ion binding