Rabbit anti-Human, Mouse C9 Polyclonal Antibody | anti-C9 antibody

C9 Polyclonal Antibody

Cat. Num. AAA3007241

• Gene Names: C9; C9D; ARMD15
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: C9; Polyclonal Antibody; C9 Polyclonal Antibody; Bcl10-interacting CARD protein; BinCARD; C9orf89; anti-C9 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: C9 polyclonal antibody detects endogenous levels of C9 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 559

• Applicable Applications for anti-C9 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human C9.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of C9orf89 polyclonal antibody at 1:500 dilutionLine1:Hela whole cell lysateLine2:H9C2 whole cell lysate)

Related Product Information for anti-C9 antibody

C9 is a plasma protein synthesized in the liver and monocytes consisting of a single polypeptide chain. C9 is a part of the membrane attack complex (MAC), an important component of the immune system. The MAC forms upon complement system activation by invading pathogenic bacteria and consists of the four major complement proteins: C5b, C6, C7 and C8. These complement proteins bind to the outer surface of the plasma membrane of the invading cell. C9 binds to the membrane associated C5b-8 protein, which leads to the circular polymerization of 12-18 C9 molecules. These polymerized C9 molecules form a ring structure in the membrane. Molecules can then diffuse freely through this transmembrane channel, causing cell lysis and destruction of the invading bacterial cell.

NCBI and Uniprot Product Information

• NCBI GI #: 4502511
• NCBI GeneID: 735
• NCBI Accession #: NP_001728.1
• NCBI GenBank Nucleotide #: NP_001728.1
• UniProt Accession #: P02748
• Molecular Weight: ~ 20kDa
• NCBI Official Full Name: complement component C9 preproprotein
• NCBI Official Synonym Full Names: complement C9
• NCBI Official Symbol: C9
• NCBI Official Synonym Symbols: C9D; ARMD15
• NCBI Protein Information: complement component C9
• UniProt Protein Name: Complement component C9
• Protein Family: Complement component
• UniProt Gene Name: C9
• UniProt Entry Name: CO9_HUMAN

NCBI Description

This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency. [provided by RefSeq, Feb 2009]

Uniprot Description

C9: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC. Defects in C9 are a cause of complement component 9 deficiency (C9D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.

Protein type: Membrane protein, multi-pass; Extracellular matrix; Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 5p14-p12

Cellular Component: membrane attack complex; integral to plasma membrane; cytoplasm; extracellular region; plasma membrane

Biological Process: complement activation, alternative pathway; regulation of complement activation; innate immune response; hemolysis by symbiont of host red blood cells; complement activation, classical pathway

Disease: Macular Degeneration, Age-related, 15; Complement Component 9 Deficiency