Rabbit anti-Human C8orf4 Polyclonal Antibody | anti-C8orf4 antibody

C8orf4 Antibody

Cat. Num. AAA7044364

• Gene Names: C8orf4; TC1; TC-1
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen Affinity Purified
• Synonyms: C8orf4; Polyclonal Antibody; C8orf4 Antibody; Protein C8orf4; Thyroid cancer protein 1; TC-1; anti-C8orf4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 106

• Applicable Applications for anti-C8orf4 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: Recommended dilution: IHC: 1:20-1:200
• Species: Human
• Immunogen: Recombinant human Protein C8orf4 protein (1-106AA)
• Conjugate: Non-conjugated
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-98165
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human small intestine tissue using MBS7044364 at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human lung cancer tissue using MBS7044364 at dilution 1:100)

Related Product Information for anti-C8orf4 antibody

Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1 (PubMed:16424001, PubMed:16730711). Enhances the proliferation of follicular dendritic cells (PubMed:16730711). Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle (PubMed:18959821). In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity (PubMed:19684084). Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (PubMed:17603013). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis (PubMed:15087392, PubMed:24941347). However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (PubMed:25985737).

NCBI and Uniprot Product Information

• NCBI GI #: 9910148
• NCBI GeneID: 56892
• NCBI Accession #: NP_064515.1
• NCBI GenBank Nucleotide #: NM_020130.4
• UniProt Accession #: Q9NR00
• Molecular Weight: 12,337 Da
• NCBI Official Full Name: protein C8orf4
• NCBI Official Synonym Full Names: chromosome 8 open reading frame 4
• NCBI Official Symbol: C8orf4
• NCBI Official Synonym Symbols: TC1; TC-1
• NCBI Protein Information: protein C8orf4
• UniProt Protein Name: Protein C8orf4
• Protein Family: Protein
• UniProt Gene Name: C8orf4
• UniProt Synonym Gene Names: TC-1
• UniProt Entry Name: CH004_HUMAN

NCBI Description

This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]

Uniprot Description

C8orf4: May decrease apoptosis.

Chromosomal Location of Human Ortholog: 8p11.2

Cellular Component: cytoplasm; nuclear speck; nucleolus; nucleus

Molecular Function: Notch binding; protein binding

Biological Process: endothelial cell activation during immune response; negative regulation of Notch signaling pathway; positive regulation of NF-kappaB import into nucleus; regulation of transcription in response to stress